Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis.

Ophthalmology
Diana E FisherMary Frances Cotch

Abstract

To describe the incidence of age-related macular degeneration (AMD) and associated risk factors in 4 racial/ethnic groups (white, black, Hispanic, and Chinese) residing in the United States. Prospective cohort study. A total of 3811 participants, aged 46 to 86 years, from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort, with retinal data collected twice, on average, 8 years apart. Fundus images, taken using a digital camera through dark-adapted pupils using a standard protocol and the same equipment at both study visits, were graded centrally for early and late AMD on the basis of drusen size, type and area, increased retinal pigment, retinal pigment epithelial depigmentation, neovascular lesions, and geographic atrophy using the modified Wisconsin Age-Related Maculopathy Grading System. Demographic, clinical, and laboratory measures were included in multivariable regression models to determine their impact on the variation in AMD incidence among racial/ethnic groups. Incident early and late AMD. The overall 8-year age- and sex-standardized incidence of early and late AMD were 4.1% and 2.3%, respectively, with incidence of early and late AMD highest in whites (5.3% and 4.1%, respectively), intermediate in Chinese (4.5% ...Continue Reading

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Citations

Mar 13, 2020·JAMA Ophthalmology·Sharon H SaydahMary Frances Cotch
Jul 12, 2020·Scientific Reports·Dong Hoon ShinDon-Il Ham
Jan 6, 2021·Photodiagnosis and Photodynamic Therapy·Nedime Sahinoglu-Keskek, Figen Sermet
Dec 9, 2020·Asia-Pacific Journal of Ophthalmology·Martine J Jager, Johanna M Seddon
Feb 28, 2021·The British Journal of Ophthalmology·Ryan Eyn Kidd ManEcosse Luc Lamoureux
May 8, 2021·Nature Reviews. Disease Primers·Monika FleckensteinEmily Y Chew
Jul 3, 2021·Journal of Clinical Medicine·Enrique García-GenF Bosch-Morell

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