Abstract
Motor neuron disease (MND) is a severe neurodegenerative disease with largely unknown etiology. Most epidemiological studies are hampered by small sample sizes and/or the retrospective collection of information on behavioural and lifestyle factors. 1.3 million women from the UK Million Women Study, aged 56 years on average at recruitment, were followed up for incident and/or fatal MND using NHS hospital admission and mortality data. Adjusted relative risks were calculated using Cox regression models. During follow-up for an average of 9·2 years, 752 women had a new diagnosis of MND. Age-specific rates increased with age, from 1·9 (95% CI 1·3 - 2·7) to 12·5 (95% CI 10·2 - 15·3) per 100,000 women aged 50-54 to 70-74, respectively, giving a cumulative risk of diagnosis with the disease of 1·74 per 1000 women between the ages of 50 and 75 years. There was no significant variation in risk of MND with region of residence, socio-economic status, education, height, alcohol use, parity, use of oral contraceptives or hormone replacement therapy. Ever-smokers had about a 20% greater risk than never smokers (RR 1·19 95% CI 1·02 to 1·38, p = 0·03). There was a statistically significant reduction in risk of MND with increasing body mass inde...Continue Reading
References
Jan 1, 1992·Neuroepidemiology·M Elian, G Dean
Jul 1, 1991·Statistics in Medicine·D F EastonA G Babiker
Oct 26, 2001·Journal of the Neurological Sciences·P M Worms
Jun 7, 2003·Neuroepidemiology·Carmel Armon
Jun 19, 2007·Lancet·J D Mitchell, G D Borasio
Nov 8, 2007·BMJ : British Medical Journal·Gillian K ReevesUNKNOWN Million Women Study Collaboration
Nov 23, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Thomas G DayPat Doyle
Dec 15, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·G LogroscinoUNKNOWN EURALS
May 29, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A AlonsoM A Hernán
Aug 28, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·Giancarlo LogroscinoUNKNOWN EURALS
Nov 18, 2009·Neurology·Carmel Armon
Jan 16, 2010·BMC Neurology·Alvaro AlonsoMiguel A Hernán
Jun 23, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·John Douglas MitchellMary R O'Brien
Jul 20, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Alvaro AlonsoMiguel A Hernán
Nov 23, 2010·Neuroepidemiology·Benoît MarinGiancarlo Logroscino
Jan 19, 2011·BMC Medical Research Methodology·Benjamin J CairnsDiana Kuh
Feb 8, 2011·Lancet·Matthew C KiernanMargaret C Zoing
Mar 31, 2011·British Journal of Cancer·R Peto
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Miranda E G ArmstrongUNKNOWN Million Women Study Collaborators
Citations
Jul 19, 2014·Occupational and Environmental Medicine·Neil Pearce, Hans Kromhout
Mar 20, 2014·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Elena RuizUNKNOWN Spain RDR Working Group
Mar 13, 2016·European Journal of Epidemiology·Valentina GalloPaolo Vineis
Mar 1, 2017·PloS One·Sophie HorrocksCathie L M Sudlow
Oct 5, 2017·European Journal of Epidemiology·Raphael Simon PeterAlbert Christian Ludolph
Jun 28, 2019·Neurology·Ola NakkenTrygve Holmøy
Apr 12, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Elisa BaldinUNKNOWN FRALIM CONSORTIUM
Dec 20, 2018·Neurology. Clinical Practice·Efthimios DardiotisAlexandros G Brotis
Feb 26, 2019·Journal of Neurology·Danielle J LeightonUNKNOWN CARE-MND Consortium
Jun 7, 2018·International Journal of Epidemiology·Jane GreenUNKNOWN Million Women Study Collaborators
Apr 3, 2019·Frontiers in Neurology·Siobhan E KirkShyuan T Ngo
Jun 11, 2019·Frontiers in Neurology·Ping ZengHaibo Xu
Mar 7, 2021·Journal of Personalized Medicine·Nupur NagMichele Levin
May 7, 2021·PloS One·Ikjae LeePeter H King