Incidence of and risk factors for motor neurone disease in UK women: a prospective study.

BMC Neurology
Pat DoyleJane Green

Abstract

Motor neuron disease (MND) is a severe neurodegenerative disease with largely unknown etiology. Most epidemiological studies are hampered by small sample sizes and/or the retrospective collection of information on behavioural and lifestyle factors. 1.3 million women from the UK Million Women Study, aged 56 years on average at recruitment, were followed up for incident and/or fatal MND using NHS hospital admission and mortality data. Adjusted relative risks were calculated using Cox regression models. During follow-up for an average of 9·2 years, 752 women had a new diagnosis of MND. Age-specific rates increased with age, from 1·9 (95% CI 1·3 - 2·7) to 12·5 (95% CI 10·2 - 15·3) per 100,000 women aged 50-54 to 70-74, respectively, giving a cumulative risk of diagnosis with the disease of 1·74 per 1000 women between the ages of 50 and 75 years. There was no significant variation in risk of MND with region of residence, socio-economic status, education, height, alcohol use, parity, use of oral contraceptives or hormone replacement therapy. Ever-smokers had about a 20% greater risk than never smokers (RR 1·19 95% CI 1·02 to 1·38, p = 0·03). There was a statistically significant reduction in risk of MND with increasing body mass inde...Continue Reading

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Citations

Jul 19, 2014·Occupational and Environmental Medicine·Neil Pearce, Hans Kromhout
Mar 20, 2014·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Elena RuizUNKNOWN Spain RDR Working Group
Mar 13, 2016·European Journal of Epidemiology·Valentina GalloPaolo Vineis
Oct 5, 2017·European Journal of Epidemiology·Raphael Simon PeterAlbert Christian Ludolph
Jun 28, 2019·Neurology·Ola NakkenTrygve Holmøy
Apr 12, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Elisa BaldinUNKNOWN FRALIM CONSORTIUM
Dec 20, 2018·Neurology. Clinical Practice·Efthimios DardiotisAlexandros G Brotis
Feb 26, 2019·Journal of Neurology·Danielle J LeightonUNKNOWN CARE-MND Consortium
Jun 7, 2018·International Journal of Epidemiology·Jane GreenUNKNOWN Million Women Study Collaborators
Apr 3, 2019·Frontiers in Neurology·Siobhan E KirkShyuan T Ngo

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

STATA

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