Abstract
Despite the fact that malignancies are associated with hematological abnormalities, some clinical studies have been unable to detect such a relation. The aim of our study was to detect the prevalence of pretreatment hematologic abnormalities in patients with common solid tumors and to determine if such a profile could be used for prognostic evaluations. We identified all patients in Cancer Center of Sun Yat-sen University who were diagnosed as solid tumors (breast carcinoma, hepatocellular carcinoma, nasopharyngeal carcinoma, esophageal carcinoma, gastric cancer, cervical carcinoma, endometrial cancer, renal cell carcinoma, and non-small cell lung cancer) between January 2000 and August 2009. All subjects were investigated regarding levels of white blood cells, platelets, and hemoglobin concentration. We identified 3,180 patients with solid tumors and 285 patients with benign diseases for the final analysis. The percentages of leukocytosis, anemia, and thrombocytosis in patients with solid tumors ranged from 4.0% to 25.6%, 3.3% to 29.2%, and 2.1% to 9.7%, respectively. The multivariate Cox analysis revealed that anemia was an independent prognostic factor in patients with breast cancer (P = 0.006), hepatocellular carcinoma (P =...Continue Reading
References
Apr 1, 1996·Hematology/oncology Clinics of North America·A R Moliterno, J L Spivak
Sep 1, 1996·The European Respiratory Journal·L M Pedersen, N Milman
May 1, 1997·British Journal of Haematology·A DowlatiY Beguin
Aug 10, 2000·BJU International·N P SymbasJ A Petros
Aug 15, 2000·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·L HeflerC Tempfer
Jun 20, 2001·Cancer·J J CaroG Goss
Dec 18, 2001·Cancer·I KasugaK Ohyashiki
Mar 30, 2002·Annals of Surgical Oncology·Masataka IkedaTakashi Satomi
Jun 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Juergen DunstGabriele Haensgen
Jan 31, 2004·Gynecologic Oncology·Andrew J LiBeth Y Karlan
Mar 19, 2004·Urology·Cağatay GöğüşYaşar Bedük
Apr 28, 2004·Journal of the American College of Surgeons·Hideaki ShimadaTakenori Ochiai
Mar 3, 2005·Cancer·Dirk RadesVolker R Rudat
Jun 16, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C-C ChenJ-P Gau
Aug 22, 2006·Oral Oncology·Chia Chun LuChung Ji Liu
Aug 29, 2006·Gynecologic Oncology·Dimitry L LernerAndrew J Li
Mar 21, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Barbara MroczkoMaciej Szmitkowski
May 17, 2007·Neuro-oncology·Marc A BrockmannChristoph Groden
Sep 14, 2007·Urologia Internationalis·Fikret ErdemirKoray Erten
Feb 26, 2008·Nature Cell Biology·Muh-Hwa YangKou-Juey Wu
May 13, 2008·Archives of Gynecology and Obstetrics·Tayfun GungorLeyla Mollamahmutoglu
May 27, 2008·Interactive Cardiovascular and Thoracic Surgery·Masaki TomitaToshio Onitsuka
Jun 11, 2008·Journal of Cancer Research and Clinical Oncology·Jale Metindir, Gülay Bilir Dilek
Jun 19, 2008·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·M BaghiR Knecht
Jun 25, 2009·Journal of Cancer Research and Clinical Oncology·Ming-Huang ChenMuh-Hwa Yang
Mar 26, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Miao-zhen QiuRui-hua Xu
Citations
Jun 15, 2012·BMC Cancer·Chia-Lin HsuPan-Chyr Yang
May 28, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·An-Chuan LiChong Zhao
Jun 5, 2013·Head & Neck·Yu-Duan TsaiJer-Yiing Houng
Sep 1, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·L HanY Cheng
Mar 26, 2015·Annals of Surgical Oncology·Eun Young KimKyo Young Song
Jan 1, 2014·Head & Neck·Chuangzhen ChenDerui Li
Apr 3, 2012·Gynecologic Oncology·Michael J WorleyColleen M Feltmate
Feb 11, 2015·Oncology Letters·Yu-Pei ChenYun-Fei Xia
Sep 6, 2013·Gynecologic Oncology·Tormund S NjølstadJone Trovik
Sep 4, 2015·PloS One·Zhen SuFang-Yun Xie
Oct 8, 2016·BMC Cancer·Thomas GrelletyAntoine Italiano
Aug 12, 2017·Cancer Biomarkers : Section a of Disease Markers·Yi-Sheng WeiJun Huang
Dec 5, 2017·BMC Cancer·Sara Falk JørgensenSigne Westring Worm
Jun 28, 2014·Journal of Leukocyte Biology·Simone Cardozo StoneAna Paula Lepique
Feb 5, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Nora SchweitzerArndt Vogel
Sep 15, 2017·Oncotarget·Katsumi KozasaTadashi Kimura
Feb 18, 2017·Oncotarget·Juan ChengMixuan Yi
Jan 14, 2017·Oncotarget·Antoine SchernbergEric Deutsch
Jun 20, 2014·Experimental and Therapeutic Medicine·Changyuan HuXian Shen
Mar 5, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Ying ChenXiang-Yu Liu
Feb 20, 2016·Molecular and Clinical Oncology·Pinzhu HuangYunfei Yuan
Mar 15, 2016·World Journal of Gastroenterology : WJG·Xiao-Feng ChenYong-Qian Shu
Feb 22, 2013·Oncology Letters·Xiao-Chun ZhaoJian-Guo Cao
Dec 12, 2018·BMC Cancer·Yaqi HuangPeiguo Wang
Aug 4, 2019·World Journal of Surgical Oncology·Weijuan CaoLiyong Xu
Dec 3, 2014·The International Journal of Biological Markers·Miaozhen QiuRui-hua Xu
Aug 9, 2020·Curēus·Mazen M Almehmadi
Apr 26, 2017·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Marília Berlofa VisacriPatricia Moriel
Oct 27, 2017·Scientific Reports·Kyueng-Whan MinYoung Chan Wi
Apr 22, 2020·BMC Pulmonary Medicine·Yuan YuanYingying Qian
Aug 6, 2013·Cancer Research·Alexander SioKenneth W Harder
Nov 6, 2020·Cancer Management and Research·Yao TongPengming Sun
Mar 10, 2021·BMC Cancer·Dongdong ZhouZhiyun Yang
Jul 24, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ahmed Abu-ZaidIsmail Abdulrahman Al-Badawi
Jul 29, 2021·Critical Reviews in Food Science and Nutrition·Muthu ThiruvengadamKannan R R Rengasamy