Incidence of aspirin resistance in the patient group of a university hospital in Korea

The Korean journal of laboratory medicine
Young Kyung LeeHee Jung Kang

Abstract

Aspirin is the most common drug used for the prevention of arterial thrombosis. However, platelet responsiveness to aspirin is variable among individuals and it is important to detect aspirin resistance to improve clinical outcome. We analyzed the changes of platelet reactivity before and after aspirin treatment. We also investigated the incidence and influencing factors of aspirin resistance in Korean. We tested platelet function in 198 patients who had been treated with aspirin in a Korean university hospital, and 59 of these patients were tested for platelet function before and after aspirin treatment. We also analyzed platelet reactivity in 136 patients who had not been treated with aspirin. Platelet function was tested using the VerifyNow Aspirin Assay (Accumetrics, USA). Platelet reactivity was expressed as aspirin reaction unit (ARU) and > or =550 ARU was defined as aspirin resistance. Platelet reactivity of 136 patients who had not been treated with aspirin was 632.2plusmn;46.3 ARU (meanplusmn;SD) (range, 462-675). Platelet reactivity of 198 patients who had been treated with aspirin was 472.5plusmn;60.0 (338-666) ARU, and 10.1% of patients were aspirin-resistant. The difference of platelet reactivity before and after a...Continue Reading

References

Jul 27, 2001·The American Journal of Cardiology·P A GumE J Topol
May 8, 2002·Journal of Thrombosis and Thrombolysis·Josie A Cambria-Kiely, Pritesh J Gandhi
Feb 15, 2003·Thrombosis Research·Kjell AndersenIngebjørg Seljeflot
Dec 13, 2003·Stroke; a Journal of Cerebral Circulation·Mark J AlbertsJun Teruya
Dec 17, 2003·The American Journal of Cardiology·John C WangDaniel I Simon
Feb 14, 2004·Stroke; a Journal of Cerebral Circulation·Askiel BrunoNils U Bang
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Alex MalininVictor Serebruany
Dec 23, 2004·Journal of Thrombosis and Haemostasis : JTH·N A ZakaiM Cushman
Jul 2, 2005·The American Journal of Medicine·Pui-Yin LeeChu-Pak Lau
Aug 23, 2006·The American Journal of Cardiology·Ahmadshah MirkhelMichael Domanski
Jun 15, 2007·Thrombosis Research·P FontanaP de Moerloose
Feb 16, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·David L McGlasson, George A Fritsma

❮ Previous
Next ❯

Citations

Apr 12, 2014·Genetic Testing and Molecular Biomarkers·Bei-Yun Wang, Shi-Jin Tan
Nov 10, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Serdar SevimliSerhat Vançelik
Oct 5, 2010·The Journal of Clinical Hypertension·Beste OzbenOguz Caymaz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.