Abstract
Atherosclerotic cardiovascular disease (ASCVD) is increasing in incidence in persons with human immunodeficiency virus (HIV). It is not known whether the morbidity and mortality rate of ASCVD is similarly increasing among patients with HIV end-stage renal disease (ESRD), who are living longer since the initiation of newer therapeutic regimens in 1997. We conducted a population-based study of 8,312 HIV ESRD patients enrolled in the US Renal Data System from 1987 to 2001. We determined the incidence of fatal and nonfatal ASCVD events stratified by date of dialysis therapy initiation. There were 3,112 HIV ESRD patients (77.9% men; mean age, 39.6 +/- 9.6 years) who initiated dialysis therapy before 1997 and 2,371 patients (71.5% men; mean age, 41.3 +/- 9.7 years) who initiated dialysis therapy after 1997. Cumulative incidences of ASCVD for those initiating dialysis therapy before 1997 compared with after 1997 were 10.6% versus 13.5% at 12 months, 18.8% versus 27.6% at 24 months, 26.2% versus 42.4% at 36 months, and 33.7% versus 65.9% at 48 months (P < 0.0001 by log rank). Those who initiated dialysis therapy after 1997 had a greater risk for developing ASCVD (adjusted hazard ratio, 1.57; 95% confidence interval, 1.29 to 1.92) than ...Continue Reading
References
Oct 15, 1993·Annals of Internal Medicine·J G JollisD B Mark
Sep 26, 1997·Neurology·C BeneschD B Matchar
Mar 27, 1998·The New England Journal of Medicine·F J PalellaS D Holmberg
Jun 10, 1998·AIDS·A CarrD A Cooper
Jul 4, 1998·Lancet·A CarrD A Cooper
Jul 8, 1998·Lancet·G BehrensR E Schmidt
Nov 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R N FoleyM J Sarnak
Mar 20, 1999·Kidney International. Supplement·G Weiss
Mar 27, 1999·Lancet·B LedergerberR Weber
Apr 15, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M J Sarnak, A S Levey
Jan 11, 2000·AIDS·P MaggiG Pastore
Mar 29, 2001·AIDS·M DepaironUNKNOWN Swiss HIV Cohort Study
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·George A Kaysen
Jul 4, 2001·Annals of Internal Medicine·E L MurphyUNKNOWN Viral Activation Transfusion Study Investigators
May 31, 2002·Clinical Nephrology·M J SarnakA S Levey
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Tejinder S AhujaShilpi Khan
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·J Craig LongeneckerMichael J Klag
Feb 21, 2003·The New England Journal of Medicine·Samuel A BozzetteThomas A Louis
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Rudolph A RodriguezPatricia Schoenfeld
May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tejinder S AhujaShilpi Khan
May 20, 2003·Kidney International·Lynda Anne SzczechUNKNOWN Adult AIDS Clinical Trial Group Renal Complications Committee
Jul 3, 2003·BMC Nephrology·Kevin C AbbottTejinder S Ahuja
Jul 19, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Judith S CurrierSally Hodder
Oct 10, 2003·Advances in Cardiology·Daniel VittecoqGilles Chironi
Nov 25, 2003·The New England Journal of Medicine·Nina Friis-MøllerUNKNOWN Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group
Apr 20, 2004·Current Opinion in Nephrology and Hypertension·Josef CoreshMark J Sarnak
Jul 15, 2004·Seminars in Dialysis·Jerome I TokarsMatthew J Arduino
Sep 2, 2004·Journal of the American Society of Nephrology : JASN·Paul W Eggers, Paul L Kimmel
Feb 22, 2005·The American Journal of Cardiology·Steven A GroverJayanti Mukherjee
Mar 25, 2005·Journal of the American Society of Nephrology : JASN·Rulan S ParekhMichael J Klag