Incidence of Bcl-2 expression in bladder cancer: relation to schistosomiasis

Clinical Biochemistry
Menha SwellamHosni Khiry

Abstract

Apoptosis (programmed cell death) and the genes regulating this process (e.g., Bcl-2) have recently become a focus of interest in the study of cancer development and progression. The bcl-2 gene product plays a role as an inhibitor of apoptosis; it contributes to oncogenesis by suppressing signals that induce apoptotic cell death. The aim of this study was to determine the expression of bcl-2 in schistosomal bladder cancer and to compare it with the established clinicopathological factors. Tumor tissues from 118 patients with bladder cancer were examined [57 with squamous cell carcinoma (SCC) and the remaining 61 with transitional cell carcinoma (TCC)]. Of 118 patients, 60 had schistosomiasis associated with bladder cancer. Bcl-2 expression was determined by enzyme immunoassay and the results were confirmed by Western blot and immunodot blot techniques. Bcl-2 was significantly expressed in SCC compared to those with TCC type in the presence of schistosomiasis. Moreover, bcl-2 was associated with clinical stages and lymph node involvement but not with histological grades. These observations detect a potential role for bcl-2 expression in schistosomal carcinogenesis, and hence selecting patients for future anti-bcl-2 therapy.

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Citations

Feb 22, 2012·Parasite : Journal De La Société Française De Parasitologie·S BenamrouzG Certad
Oct 15, 2009·Parasite Immunology·B J Vennervald, K Polman
Mar 17, 2009·International Journal for Parasitology·Mónica BotelhoJosé Manuel Correia da Costa
Jan 30, 2019·Journal of Cellular Physiology·Mostafa KhafaeiMahmood Tavallaie
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Liang WangJung Wook Park

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