Incidence of birth defects after artificial insemination with frozen donor spermatozoa: a collaborative study of the French CECOS Federation on 11,535 pregnancies

Human Reproduction
François ThepotP Jalbert

Abstract

Artificial insemination using cryogenically preserved spermatozoa has been widely used in human reproduction for several decades. No evaluation of the resulting pregnancies and conceptions has been undertaken in sufficiently large study populations for minor variations to be distinguished. This study involves 11,535 pregnancies conceived by artificial insemination using donor spermatozoa and followed from the time that pregnancy was diagnosed. The pregnancies followed a normal course with, in particular, no excessive fetal losses. While the global incidence of birth defects was similar to that of natural conception, our observations raise doubts concerning trisomy 21. The frequency of trisomy 12 was somewhat elevated when compared with French malformation registries. A recruitment bias could, in part, explain this discrepancy, but donor age cannot be excluded as an influencing factor.

Citations

Apr 18, 2006·Fertility and Sterility·Elise de La RochebrochardUNKNOWN French National IVF Registry (FIVNAT) Association
Aug 30, 2005·Gynécologie, obstétrique & fertilité·J-P Siffroi, UNKNOWN Commission de Génétique de la Fédération Française des CECOS
Jul 21, 2001·European Journal of Human Genetics : EJHG·M BoschC Templado
Nov 15, 2005·Human Reproduction·S PaulJ A Stewart

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Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

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