Incidence of bleeding in patients with atrial fibrillation and advanced liver fibrosis on treatment with vitamin K or non-vitamin K antagonist oral anticoagulants

International Journal of Cardiology
Daniele PastoriATHERO-AF Study Group

Abstract

To investigate the incidence of bleeding events in atrial fibrillation (AF) patients treated with vitamin K (VKAs) or non-vitamin K antagonist oral anticoagulants (NOACs) screened for the presence of liver fibrosis (LF). Previous studies provided conflicting results on bleeding risk in AF patients with liver disease on VKAs, and no data on NOACs in this setting are available. Post-hoc analysis of a prospective, observational multicentre study including 2330 AF outpatients treated with VKAs (n = 1297) or NOACs (n = 1033). Liver damage was quantified by the FIB-4 score (>3.25), a validated marker of LF. The primary endpoint was the incidence of any bleeding, according to ISTH classification. A high FIB-4 was present in 129 (5.5%) patients: 77 (5.9%) on VKA and 52 (5.0%) on NOACs (p = 0.344). During follow-up, 357 (15.3%) patients experienced a bleeding: 261 (80 major and 180 minor) with VKAs (7.2%/year), and 96 (40 major and 56 minor) with NOACs (6.4%/year). In VKA-treated patients, but not in those on NOACs, FIB-4 >3.25 was associated with higher major bleeding (14.3% vs. 5.6%, log-rank test p < 0.001). Multivariable Cox regression model showed that FIB-4 was associated with major bleeding only in VKA-treated patients (HR: 3.075...Continue Reading

Citations

Nov 20, 2018·European Journal of Gastroenterology & Hepatology·Ronpichai ChokesuwattanaskulWisit Cheungpasitporn
Sep 6, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Yonghui FuWenfeng He
Sep 9, 2020·European Journal of Clinical Investigation·Danilo MenichelliUNKNOWN CAR
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Jan 8, 2020·Stroke; a Journal of Cerebral Circulation·Neal S ParikhUNKNOWN VISTA-ICH Collaborators
Mar 28, 2019·Frontiers in Cardiovascular Medicine·Daniele PastoriFrancesco Violi
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Oct 20, 2020·Internal and Emergency Medicine·Francesco VioliDaniele Pastori
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Mar 18, 2021·Journal of Thrombosis and Thrombolysis·Sarah A NislyJanine Tillett
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