PMID: 11928828Apr 4, 2002Paper

Incidence of cardiovascular disease, cancer and death in postmenopausal women affirming use of hormone replacement therapy

Scandinavian Journal of Public Health
Bo HedbladLars Janzon

Abstract

The goal of this study was to evaluate the incidence of myocardial infarction, cancer and death in relation to use of hormone replacement therapy (HRT). Nine years' follow up of an urban cohort of peri-/postmenopausal women was undertaken. Local and national registers were used for retrieval of events. The incidence of myocardial infarction per 1.000 person-years in users and non-users was 0.61 (5/962) and 2.20 (92/4759) respectively, adjusted relative risk (RR) 0.37; 95% confidence interval 0.15-0.90. Rates of mortality from cardiovascular disease and cancer were 0.36 and 1.10, p= 0.058, and 2.60 and 2.09, p=0.360 respectively. In terms of all-cause mortality the adjusted RR was 1.02; 0.69-1.52, incidence of cancer 1.28; 1.01-1.64, breast cancer 1.52; 1.01-2.28 and endometrial cancer 3.61; 1.54-8.46. Women affirming use of HRT had a lower incidence of myocardial infarction. Further studies are needed to assess whether the absence of effect on total mortality may be accounted for by an increased cancer risk.

Citations

Aug 10, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·P Ha-VinhL Sauze
Jul 20, 2004·Journal of Internal Medicine·E JanzonG Engström
Jul 18, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Seung Min Oh, Kyu Hyuck Chung
May 1, 2004·American Journal of Obstetrics and Gynecology·Michelle P Warren
Nov 9, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Monika Puzianowska-Kuźnicka

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