PMID: 25735341Mar 5, 2015Paper

Incidence of cisplatin-induced nephrotoxicity and associated factors among cancer patients in Indonesia

Asian Pacific Journal of Cancer Prevention : APJCP
Yenny PrasajaRetnosari Andrajati

Abstract

Cisplatin is still used as a first-line medication for solid tumors. Nephrotoxicity is a serious side effect that can decrease renal function and restrict applicable doses. This research aimed to obtain the profile of cisplatin-induced nephrotoxicity and its associated factors in adult cancer patients at Dharmais National Cancer Hospital (DNCH). The design was cross-sectional with data obtained from patient medical records. We retrospectively reviewed adult cancer patients treated with cisplatin ≥60mg/m2 for at least four consecutive chemotherapy cycles from August 2011 to November 2013. The nephrotoxicity criterion was renal function decline characterized by creatinine clearance <60 ml/min using the Cockroft-Gault (CG) equation. Eighty-eight subjects received at least four chemotherapy cycles of cisplatin. The prevalence of cisplatin nephrotoxicity was 34.1%. Symptoms could be observed after the first cycle of chemotherapy, and the degree of renal impairment was higher with increased numbers of cycles (r=-0.946, r2=89.5%). Factors that affected the decline of renal function were patient age (p=0.008, OR=3.433, 95%CI= 1.363-8.645) and hypertension (p=0.026, OR=2.931, 95%CI=1.120-7.670). Cisplatin nephrotoxicity occurred in more...Continue Reading

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Citations

Apr 2, 2016·Pharmacognosy Research·Oluwatosin Adekunle AdaramoyeOlufunke Elizabeth Ola-Davies
Dec 1, 2015·Basic & Clinical Pharmacology & Toxicology·Mohamed A Morsy, Gehan H Heeba
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Jan 21, 2021·Experimental Biology and Medicine·Si-Yang WangXiang-Mei Chen
May 14, 2021·Clinical and Translational Science·Mitsuhiro GodaKeisuke Ishizawa

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