Incidence of contrast-induced nephropathy in kidney transplant recipients

Transplantation Proceedings
M HaiderV Karthikeyan

Abstract

Contrast-induced nephropathy (CIN) is responsible for one-third of acute kidney injuries (AKI) in the hospital setting. The incidence of CIN varies from 3% to 30%, depending on the preexisting risk factors, with higher incidence noted with diabetes mellitus, chronic kidney disease, and older age. Though CIN risk factors are common in kidney transplant recipients (KTRs), data about incidence of CIN in this population are sparse. We retrospectively analyzed 124 consecutive patients transplanted at our center between January 2002 and December 2013 and received iodinated intravascular contrast with stable kidney function prior to contrast administration. CIN was defined as either an absolute rise in serum creatinine of ≥ 0.5 mg/dL or a ≥ 25% drop in estimated glomerular filtration rate (eGFR) after contrast administration. Seven of 124 (5.64%) patients developed CIN. Kidney function returned to baseline in 5 of the 7 patients within 3 weeks. In 2 patients serum creatinine remained elevated due to recurrent AKI episodes from other causes. Dialysis was not required in any patient. Calcineurin inhibitors (CNIs) were being used in 95% patients at the time of contrast administration. Diabetes mellitus, baseline serum creatinine, age, ra...Continue Reading

References

Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kevin NashSusan Hou
Feb 21, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Vanji KarthikeyanGreg Knoll
Apr 14, 2006·Kidney International. Supplement·R Mehran, E Nikolsky

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Citations

Feb 13, 2016·AJR. American Journal of Roentgenology·Ghaneh FananapazirRamit Lamba
Dec 19, 2015·Therapeutic Advances in Cardiovascular Disease·Francesco SummariaRoberto Patrizi
Jan 15, 2018·Abdominal Radiology·Praveen Ganti RanganathDavid T Fetzer
Jan 7, 2017·World Journal of Transplantation·Fedaey Mohammed AbbasAhmed Halawa
May 16, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Stan BenjamensRobert A Pol
Mar 7, 2018·Abdominal Radiology·Federica VernuccioDaniele Marin
Oct 9, 2018·QJM : Monthly Journal of the Association of Physicians·J S LeesC C Geddes
Sep 20, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Julian Alexander KelemenValentin Neuhaus
Jan 8, 2020·BMC Nephrology·Gholamhossein NaderiSeyed Mohammad Kazem Aghamir
Jun 13, 2017·Frontiers in Medicine·Bassam G Abu JawdehCharuhas V Thakar

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