PMID: 3773200Nov 28, 1986Paper

Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study

JAMA : the Journal of the American Medical Association
W P CastelliW B Kannel

Abstract

The first report from the Framingham Study that demonstrated an inverse relationship between high-density lipoprotein cholesterol (HDL-C) and the incidence of coronary heart disease (CHD) was based on four years of surveillance. These participants, aged 49 to 82 years, have now been followed up for 12 years, and this report shows that the relationship between the fasting HDL-C level and subsequent incidence of CHD does not diminish appreciably with time. Since a second measurement of HDL-C is available eight years after the initial determination, the relationship of HDL-C measurements on the same subjects at two points in time is examined. This second HDL-C measurement is also used in a multivariate model that includes cigarette smoking, relative weight, alcohol consumption, casual blood glucose, total cholesterol, and blood pressure. It is concluded that even after these adjustments, nonfasting HDL-C and total cholesterol levels are related to development of CHD in both men and women aged 49 years and older. Study participants at the 80th percentile of HDL-C were found to have half the risk of CHD developing when compared with subjects at the 20th percentile of HDL-C.

Citations

Feb 27, 2007·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Debra A SchmidtWilliam B Karesh
Nov 22, 2001·Biochemical and Biophysical Research Communications·H NotoK Tsukamoto
Jun 22, 2000·Biochemical and Biophysical Research Communications·M SuganoN Makino
May 26, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Diana R ChirovskyPhilip Barter
Dec 1, 1996·Aging : Clinical and Experimental Research·M CassaderG Pagano
Apr 27, 2001·Biochemical and Biophysical Research Communications·F BenhiziaP J Talmud
Dec 25, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Izabella C R dos Santos-WeissGeraldo Picheth
May 21, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Peter P TothMaciej Banach
Sep 17, 2014·Journal of the American Society of Hypertension : JASH·Seyed Reza MirhafezMajid Ghayour-Mobarhan
Dec 11, 2002·Journal of Internal Medicine·F Al-KhaliliK Schenck-Gustafsson
Mar 12, 2002·Acta Neurologica Scandinavica·D RyglewiczH Wehr
Feb 5, 2008·Current Atherosclerosis Reports·Mohamad NavabDaniel Marelli
Jun 5, 2013·Nutrition Reviews·Lin LinPeter J H Jones
Nov 30, 2014·Endocrinology and Metabolism Clinics of North America·Carlos G Santos-GallegoRobert S Rosenson
Sep 23, 2014·Metabolism: Clinical and Experimental·Liya Wu, Klaus G Parhofer
Jun 4, 2014·Current Atherosclerosis Reports·Angela PirilloAlberico Luigi Catapano
Jan 12, 2001·Japanese Circulation Journal·T NakamuraUNKNOWN Group of the Research for the Association between Host Origin and Atherosclerotic Diseases under the Preventive Measure for
Oct 1, 1995·Baillière's Clinical Endocrinology and Metabolism·D J Betteridge, M Khan
Jun 5, 2010·Journal of Atherosclerosis and Thrombosis·Yuki HoriuchiTakashi Miida
Aug 13, 2009·Journal of Atherosclerosis and Thrombosis·Takashi HitsumotoKohji Shirai
Aug 17, 2011·Journal of Atherosclerosis and Thrombosis·Ching-Hui HuangChin-San Liu
May 10, 2013·Clinical Pharmacokinetics·Amir Hooshang Mohammadpour, Fatemeh Akhlaghi
Dec 1, 1991·The Journal of Clinical Investigation·C J MannB E Bihain
Feb 1, 1991·The Journal of Clinical Investigation·S EricssonB Angelin
Feb 3, 1990·BMJ : British Medical Journal·E M DamsgaardC E Mogensen
Jun 1, 1990·Journal of Epidemiology and Community Health·G J MillerS G Price
Apr 15, 1989·BMJ : British Medical Journal·D J Betteridge
Aug 26, 1989·BMJ : British Medical Journal·L O HughesE B Raftery

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.