Incidence of dementia after age 90 in a multiracial cohort

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Paola GilsanzRachel A Whitmer

Abstract

Little is known about dementia incidence in diverse populations of oldest-old, the age group with highest dementia incidence. Incident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated health care system in California (n = 1702 whites, n = 375 blacks, n = 105 Latinos, n = 168 Asians) aged ≥90 in 2010. We estimated race/ethnicity-specific age-adjusted dementia incidence rates and implemented Cox proportional hazards models and Fine and Gray competing risk of death models adjusted for demographics and comorbidities in midlife and late-life. Dementia incidence rates (n = 771 cases) were lowest among Asians (89.9/1000 person-years), followed by whites (96.9/1000 person-years), Latinos (105.8/1000 person-years), and blacks (121.5/1000 person-years). Cox regression and competing risk models estimated 28% and 36% higher dementia risk for blacks versus whites adjusting for demographics and comorbidities. Patterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude.

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Citations

Nov 9, 2019·Journal of Epidemiology and Community Health·Suhail Ismail ShiekhCharlotte Warren-Gash
Feb 9, 2021·Journal of Alzheimer's Disease : JAD·Suhail Ismail ShiekhCharlotte Warren-Gash
Feb 10, 2021·Current Opinion in Neurology·Claudia H KawasMaría M Corrada
Feb 2, 2022·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Eleanor Hayes-LarsonElizabeth Rose Mayeda

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