Incidence of extra-articular manifestations in ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis: results from a national register-based cohort study.

Rheumatology
Karin BengtssonLennart T Jacobsson

Abstract

To estimate the incidence and strength of association of extra-articular manifestations [EAMs, here: anterior uveitis (AU), IBD and psoriasis] in patients with AS, undifferentiated SpA (uSpA) and PsA, compared with controls. Three mutually exclusive cohorts of patients aged 18-69 years with AS (n = 8517), uSpA (n = 10 245) and PsA (n = 22 667) were identified in the Swedish National Patient Register 2001-2015. Age-, sex- and geography-matched controls were identified from the Swedish Population Register. Follow-up began 1 January 2006, or six months after the first SpA diagnosis, whichever occurred later, and ended at the first date of the EAM under study, death, emigration, 70 years of age, and 31 December 2016. Incidence rates (IRs) and incidence rate ratios were calculated for each EAM, and stratified by sex and age. Incidence rate ratios for incident AU, IBD and psoriasis were significantly increased in AS (20.2, 6.2, 2.5), uSpA (13.6, 5.7, 3.8) and PsA (2.5, 2.3, n.a) vs controls. Men with AS and uSpA had significantly higher IRs per 1000 person-years at risk for incident AU than women with AS (IR 15.8 vs 11.2) and uSpA (IR 10.1 vs 6.0), whereas no such sex difference was demonstrated in PsA or for the other EAMs. AU, foll...Continue Reading

References

Jun 19, 2002·Annals of Internal Medicine·Muhammad Asim Khan
Jun 22, 2005·Survey of Ophthalmology·John H ChangDenis Wakefield
Jul 28, 2006·Arthritis and Rheumatism·William TaylorUNKNOWN CASPAR Study Group
Feb 12, 2009·Rheumatology·Marena Rojas-VargasUNKNOWN Registro Español de Espondiloartritis de la Sociedad Española de Reumatología Working Group
Feb 4, 2011·Annals of the Rheumatic Diseases·E HaglundM Englund
Jun 21, 2011·Lancet·Maxime Dougados, Dominique Baeten
Apr 11, 2012·Nature Reviews. Rheumatology·John D Reveille
Sep 4, 2012·Annals of the Rheumatic Diseases·Wen-Qing LiAbrar A Qureshi
May 31, 2015·Lancet·Wolf-Henning Boehncke, Michael P Schön
Jul 30, 2015·JAMA Dermatology·Alexander EgebergPeter Riis Hansen
Mar 10, 2016·The British Journal of Dermatology·A EgebergL Skov
Nov 1, 2016·Scandinavian Journal of Gastroenterology·Gustav L JakobssonJonas F Ludvigsson
Jan 24, 2017·Lancet·Joachim Sieper, Denis Poddubnyy
Apr 19, 2017·JAMA Ophthalmology·Ching-Chi ChiShu-Hui Wang
Nov 3, 2017·Annals of the Rheumatic Diseases·Rachel CharltonUNKNOWN PROMPT study group
May 19, 2018·Expert Review of Clinical Immunology·Mikhail Protopopov, Denis Poddubnyy

❮ Previous
Next ❯

Citations

Jan 21, 2021·Journal of Clinical Medicine·Thomas El JammalPascal Sève
Mar 22, 2021·Best Practice & Research. Clinical Rheumatology·Mitsumasa KishimotoShinya Kaname
Aug 14, 2021·Nature Reviews. Disease Primers·Oliver FitzGeraldPhilip J Mease
Aug 26, 2021·Expert Opinion on Therapeutic Targets·Bilade CherqaouiMaxime Breban

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.