Incidence of functional bi-temporal connections in the human brain in vivo and their relevance to epilepsy surgery

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Diego Jiménez-JiménezGonzalo Alarcón

Abstract

The incidence of functional connections between human temporal lobes and their latencies were investigated using intracranial EEG responses to electrical stimulation with 1 msec single pulses in 91 patients assessed for surgery for treatment of epilepsy. The areas studied were amygdala, hippocampus, parahippocampal gyrus, fusiform gyrus, inferior and mid temporal gyrus. Furthermore, we assessed whether the presence of such connections are related to seizure onset extent and postsurgical seizure control. Responses were seen in any region of the contralateral temporal lobe when stimulating temporal regions in 30 patients out of the 91 (32.96%). Bi-hippocampal or bi-amygdalar projections were seen in only 5% of temporal lobes (N = 60) and between both fusiform gyri in 7.1% (N = 126). All other bilateral connections occurred in less than 5% of hemispheres. Depending on the structures, latencies ranged between 20 and 90 msec, with an average value of 60.2 msec. There were no statistical difference in the proportion of patients showing Engel Class I between patients with and without contralateral temporal connections. No difference was found in the proportion of patients showing bilateral or unilateral seizure onset among patients wi...Continue Reading

References

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Mar 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·G AlarcónC E Polkey
Apr 13, 2011·Epilepsia·Antonio ValentinGonzalo Alarcón
Jul 16, 2013·Neuroscience and Biobehavioral Reviews·Marco CataniMichel Thiebaut de Schotten
Sep 28, 2013·Brain Structure & Function·Henri J J M Van De Werd, Harry B M Uylings
Jul 30, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Diego Jiménez-JiménezGonzalo Alarcón

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Citations

Oct 27, 2015·Annals of the New York Academy of Sciences·Grace E RiceMatthew A Lambon Ralph
Aug 9, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Diego Jiménez-JiménezGonzalo Alarcón
Jul 30, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sandrine AubertFabrice Bartolomei
Jan 31, 2018·International Journal of Neural Systems·Gonzalo AlarcónDavid Martín-López
Aug 28, 2019·The European Journal of Neuroscience·Jurgen HebbinkHil G E Meijer
Dec 19, 2019·International Journal of Neural Systems·Yan CuiDaqing Guo
Jul 2, 2021·Frontiers in Neuroscience·Kaijia SunLiang Wang

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