Incidence of gastrointestinal bleeding in patients with cardiovascular disease: buffered aspirin versus enteric-coated aspirin

Scandinavian Journal of Gastroenterology
Yoshikazu HirataTakashi Joh

Abstract

Aspirin-induced enteropathy is increasing, but whether the type of aspirin affects the gastrointestinal (GI) bleeding, especially small intestine, is unclear. The incidence of GI bleeding for buffered aspirin and enteric-coated aspirin was evaluated in patients receiving long-term low-dose aspirin (LDA) for cardiovascular (CV) diseases. This retrospective cohort study assessed overt GI bleeding, decreased hemoglobin levels suspecting small bowel blood loss, and CV death in patients taking LDA for more than 1 year (LDA group) and in patients not taking LDA (control group). The LDA group was divided into two subgroups, patients taking either buffered aspirin (buffered subgroup) or enteric-coated aspirin (enteric subgroup), and their outcomes were compared. A total of 1402 patients (LDA group 701, control group 701; median follow-up duration 1778 ± 747 days) were assessed. The incidences of overt GI bleeding and decreased hemoglobin were 3.9% and 1.4% in LDA group, respectively, significantly higher than the control group (p < 0.01; p < 0.01). In the LDA group, 3% died during the follow-up period. Ten (3.7%) in the buffered subgroup (n = 267) and 17 (3.9%) in the enteric subgroup (n = 434) developed GI bleeding (p = 0.92). One (0....Continue Reading

References

Apr 1, 1995·BMJ : British Medical Journal·J WeilP Wainwright
Mar 15, 2000·Circulation·E H Awtry, J Loscalzo
Sep 28, 2000·The American Journal of Gastroenterology·H T SørensenJ H Olsen
Jan 31, 2002·The Annals of Pharmacotherapy·Dalia W BanoobWilliam Webster
May 25, 2002·Gastrointestinal Endoscopy·G M EisenAmerican Society for Gastrointestinal Endoscopy
Aug 13, 2005·World Journal of Gastroenterology : WJG·Yoshikazu HayashiKentaro Sugano
Sep 5, 2006·Alimentary Pharmacology & Therapeutics·L Laine
Dec 5, 2006·Gastrointestinal Endoscopy·Hsu-Heng YenMaw-Soan Soon
Nov 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Toshio WatanabeTetsuo Arakawa
Dec 2, 2009·Annals of Internal Medicine·Joseph J Y SungFrancis K L Chan

Citations

Sep 11, 2014·Current Atherosclerosis Reports·Koto Ishida, Steven R Messé
Dec 17, 2014·Journal of Gastroenterology·Hiroki EndoAtsushi Nakajima
Oct 11, 2014·Expert Review of Cardiovascular Therapy·Danielle DuffyDavid J Whellan
Aug 2, 2012·Expert Opinion on Drug Metabolism & Toxicology·Marc BardouFrançoise Goirand
Jul 4, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hiroki EndoAtsushi Nakajima
Jul 16, 2019·Expert Review of Cardiovascular Therapy·Michael E PlazakStormi E Gale
Mar 9, 2013·Expert Review of Cardiovascular Therapy·Bianca RoccaFrancesca Pagliaccia

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