Incidence of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt (TIPS) according to its severity and temporal grading classification

La Radiologia medica
Paolo FonioGiovanni Gandini

Abstract

To evaluate hepatic encephalopathy (HE) incidence after transjugular intrahepatic portosystemic shunt (TIPS) and classify by gravity and frequency. This is a retrospective study of 75 patients with no previous episodes of HE who underwent TIPS between 2008 and 2014 with clinical follow-up after 6 and 12 months. Patient risk factors evaluated include age, INR (international normalized ratio), creatinine, bilirubin, and MELD score (Model for End-of-stage Liver Disease). HE was reported using two classifications: (1) gravity divided in moderate (West-Haven grades I-II) and severe (III-IV); (2) frequency divided in episodic and recurrent/persistent. Overall HE incidence was 36% at 6 months, with 12 month incidence significantly decreased to 27% (p = 0.02). 13/75 (17%) patients had one episode of moderate HE, while 3/75 (4%) patients had severe recurrent/persistent HE. Age was the only pre-TIPS risk predictor. Post-TIPS bilirubin and INR showed variations from basal values only in the presence of diagnosed HE. Bilirubin significantly increased (p = 0.03) in correlation to HE severity, whereas INR changes correlated with temporal frequency (p = 0.04). HE distribution classified for severity is similar at 6 and 12 months, whereas when...Continue Reading

References

Dec 11, 1997·AJR. American Journal of Roentgenology·D A ZuckermanC F Hildebolt
Apr 24, 2001·The American Journal of Gastroenterology·Z HassounG Pomier-Layrargues
Jul 27, 2001·The American Journal of Gastroenterology·A T BleiUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Sep 22, 2001·Clinics in Liver Disease·R de Franchis, M Primignani
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter FerenciAndres T Blei
May 28, 2005·Digestive Diseases·Andreas Ochs
Jul 10, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Christophe BureauJean Pierre Vinel
Dec 6, 2007·Journal of Clinical Gastroenterology·Alexander Zipprich
Oct 3, 2008·Cardiovascular and Interventional Radiology·Boris RadeleffGoetz Martin Richter
Sep 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajArun J Sanyal
Feb 11, 2012·Clinics in Liver Disease·Oliviero RiggioManuela Merli
Aug 14, 2012·International Journal of Hepatology·Gilles Pomier-LayrarguesPierre Perreault
Sep 22, 2012·AJR. American Journal of Roentgenology·Nicholas FidelmanRobert K Kerlan
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hendrik VilstrupPhilip Wong
Sep 4, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Keith PereiraJose M Yrizarry

❮ Previous
Next ❯

Citations

Jul 28, 2020·Journal of Gastroenterology and Hepatology·Ahmad KhanShailendra Singh
Nov 27, 2020·Journal of Clinical Medicine·Philipp SchindlerMoritz Wildgruber
Oct 25, 2020·Journal of Hepatology·Christopher F RoseRajiv Jalan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.