Incidence of hepatocellular carcinoma after interferon therapy in patients with chronic hepatitis C

The Tohoku Journal of Experimental Medicine
H OnoderaY Minami

Abstract

We examined the effect of interferon (IFN) therapy for chronic active hepatitis (CAH) C in 207 patients by estimating the incidence of hepatocellular carcinoma (HCC) after IFN therapy using the person-years method. Statistical analysis was performed using the Mantel-Haenszel chi-square test. No HCC was detected in patients with normal serum alanine aminotransferase (ALT) levels after IFN therapy (response-effect group), and in patients with both normal serum ALT levels and hepatitis C virus (HCV)-RNA clearance after IFN therapy (complete-responder group). The incidence per 100,000 person-years in the patients with elevated serum ALT level after IFN therapy (other-effects group) were 1968 and 1624, respectively. The incidence in control patients who did not achieve IFN therapy was 901. No statistically significant differences were observed between the other-effects group, non-responder group, and the control group. Our results so far suggest that normalization of the serum ALT levels and/or HCV clearance might reduce the incidence of HCC.

References

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Aug 1, 1995·The Tohoku Journal of Experimental Medicine·H OnoderaY Minami

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Citations

Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·E Tabor
May 19, 2006·Journal of Gastroenterology and Hepatology·Masafumi IkedaHiroshi Watanabe
Oct 8, 2020·Arquivos De Gastroenterologia·Lohanna Strauhs-NitschClaudia Alexandre Pontes Ivantes

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