Incidence of hepatocellular carcinoma reduced by phlebotomy treatment in patients with chronic hepatitis C

Internal Medicine
Kazushige NireiMitsuhiko Moriyama

Abstract

To determine the impact of phlebotomy on the laboratory values and the incidence of hepatocellular carcinoma (HCC) in patients with hepatitis C. Study patients with chronic hepatitis C were treated with glycyrrhizin injection and oral ursodeoxycholic acid and either with (n=52) or without (n=50) phlebotomy during the period of 2005-2012. Six phlebotomized patients had previously received interferon therapy and were subsequently excluded from the data analysis. The serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, lactate dehydrogenase, ferritin, iron and albumin, as well as the hemoglobin concentration, platelet count and prothrombin time, were determined. We compared the long-term outcomes based on the incidence of HCC and laboratory values, including the baseline serum ferritin levels, in patients treated with versus without phlebotomy. In the phlebotomy group, the mean AST and ALT levels decreased significantly at each one-year interval over five years (p<0.01), whereas the platelet counts did not. The incidence of HCC in the phlebotomized patients was significantly lower than that observed in the patients treated without ph...Continue Reading

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Citations

May 18, 2016·Annals of the New York Academy of Sciences·Thomas D CoatesVasilios Berdoukas
Feb 27, 2016·Annals of the New York Academy of Sciences·Sara ZanellaCaterina Borgna-Pignatti
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Aug 31, 2021·The American Surgeon·Naruhiko HonmyoHideki Ohdan

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