Incidence of herpes zoster and persistent post-zoster pain in adults with or without diabetes in the United States

Open Forum Infectious Diseases
J A SuayaM J Levin

Abstract

This study was designed to assess the association between diabetes and herpes zoster (HZ) and persistent post-zoster pain (PPZP). We used a United States-based, 2005-2009 retrospective observational study of medical and pharmacy claims from adults in 3 large national databases. Incidence rate ratios were used to compare HZ incidence by diabetes status. Multivariate regressions assessed the age and sex-adjusted risk of diabetes on HZ and PPZP as a function of immune competence. National projections of HZ and PPZP cases were obtained. Among 51 million enrollees (∼88 million person-years [PYs] at risk), we identified 420 515 HZ cases. Patients with diabetes represented 8.7% of the PYs analyzed but accounted for 14.5% of the HZ cases and 20.3% of the PPZP cases. The crude incidence of HZ was 78% higher (7.96 vs 4.48 cases/1000 PY; P < .01) and the rate of PPZP was 50% higher (5.97% vs 3.93%; P < .01) in individuals with diabetes than without. Individuals with diabetes had 45% higher adjusted risk of HZ (hazard ratio [HR] = 1.45; 95% confidence intervals [CIs], 1.43-1.46) and 18% higher adjusted odds of PPZP (odds ratio = 1.18; 95% CI, 1.13-1.24). The risk of HZ associated with diabetes among immune-compromised individuals was weake...Continue Reading

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Citations

Sep 22, 2017·Human Vaccines & Immunotherapeutics·Cintia Muñoz-QuilesJavier Díez-Domingo
Mar 10, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Marianthi PapagianniKonstantinos Tziomalos
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Feb 6, 2020·Open Forum Infectious Diseases·Fawziah MarraNirma Vadlamudi
Mar 3, 2021·Human Vaccines & Immunotherapeutics·Désirée van OorschotBarbara Yawn
Dec 18, 2019·Diabetes Research and Clinical Practice·Mitra Saadatian-ElahiPhilippe Vanhems
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Sep 19, 2021·The Journal of Clinical Endocrinology and Metabolism·Chun-Ta HuangMing-Chieh Tsai
Dec 6, 2017·Mayo Clinic Proceedings·Kosuke Kawai, Barbara P Yawn
Dec 8, 2021·Infectious Diseases and Therapy·Desmond CurranBarbara P Yawn

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