Incidence of Hypersensitivity Reactions During Hemodialysis

Kidney & Blood Pressure Research
Raquel EsterasEmilio González-Parra

Abstract

A recent alert from Spanish health authorities warned of a higher incidence of reported hypersensitivity reactions to hemodialysis membranes with polysulfone, in the 2017 review of acute reactions to dialyzers found only published reports in the 21st century on polysulfone and its derivatives. The aim is to assess/evaluate the current incidence and characteristics of hypersensitivity reactions in hemodialysis patients. A retrospective multicentre study in 9 Spanish hospitals evaluated patients in whom a hypersensitivity reaction required a change in dialyzer membrane. A total of 37 patients out of 1561 (2.37%) had hypersensitivity reactions and clinical, epidemiological and analytical data were available for 33 patients (2.11%). The membranes involved were polysulfone (n=23), polynephron (n=8), polyethersulfone (n=1) and polyacrylonitrile (n=1). This distribution reflected the frequency of use of membranes in the participating dialysis units. The reactions were described as type A in 18 cases and type B in 15 cases. There were no significant differences between the two types in clinical symptoms, the composition of the membrane involved, the method of sterilization, the season, or the time during the session in which they occur...Continue Reading

Citations

May 14, 2020·The International Journal of Artificial Organs·Joachim BeigeKarl-Peter Ringel
Apr 20, 2021·Kidney Research and Clinical Practice·Alba SantosAlmudena Vega
Sep 4, 2021·Current Opinion in Nephrology and Hypertension·Bernard Canaud
Sep 11, 2019·Kidney & Blood Pressure Research·Juan Martin-NavarroEmilio González-Parra

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