PMID: 9647141Jul 1, 1998Paper

Incidence of hypersensitivity reactions

The Annals of Thoracic Surgery
W Dietrich

Abstract

Aprotinin is a naturally occurring serine protease inhibitor derived from bovine lung. In common with all foreign proteins, it possesses antigenic properties and has the possibility of allergic reactions on reexposure. Data are presented on the incidence of adverse reactions to aprotinin and the time course of antibody development after initial exposure. Recommendations for reducing the risk and sequelae of these adverse reactions are emphasized and case reports are reviewed. The incidence rates of aprotinin-related reactions to date (May 1997) at the German Heart Center are 2.7% in the adult population in reexposures (5/183) and 1.2% in the pediatric population (3/254), with an overall incidence of 1.8% (8/437). With the recommended precautions, reexposure to aprotinin in patients with a high risk of bleeding is justified, and the benefits of aprotinin treatment outweigh the relative risk of a serious allergic reaction.

References

Dec 1, 1992·The Annals of Thoracic Surgery·D M CosgroveF D Loop
Jul 18, 1992·Lancet·B WüthrichS G Johansson
Jan 1, 1983·Current Medical Research and Opinion·J G FreemanA L Latner
Apr 1, 1995·Anesthesia and Analgesia·C DiefenbachW Buzello
Aug 1, 1995·Journal of Cardiothoracic and Vascular Anesthesia·P CerianaM De Amici
Jan 1, 1993·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·K SchulzeB Hausen
Jan 1, 1997·The Annals of Thoracic Surgery·A M ScheuleG Ziemer
Oct 24, 1997·The Journal of Thoracic and Cardiovascular Surgery·J WeipertW Dietrich

❮ Previous
Next ❯

Citations

Jul 6, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Charles Marc Samama
Sep 22, 2001·American Journal of Surgery·H K Kjaergard
Jun 1, 2000·Transfusion Science·D R Norfolk, J Seghatchian
Mar 21, 2000·Transfusion Science·J L Kwiatkowski, C S Manno
Aug 7, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Phillip L BeaulieuJerrold H Levy
Oct 22, 2013·Paediatric Anaesthesia·Zulfiqar AhmedMaria Zestos
Feb 1, 2005·The Annals of Thoracic Surgery·Wolfram BeierleinGerhard Ziemer
Jan 11, 2008·Paediatric Anaesthesia·S Devi ChiravuriShobha Malviya
Mar 16, 2001·Expert Opinion on Pharmacotherapy·P P PunjabiK M Taylor
Sep 29, 2006·Thoracic Surgery Clinics·Farid GharagozlooFarzad Najam
Oct 18, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Laura Engles
Jul 30, 2002·Anesthesia and Analgesia·Charles Marc SamamaPierre Coriat
Oct 4, 2006·Current Opinion in Anaesthesiology·W Dietrich
Jul 9, 2004·Orthopedics·Jerrold H Levy, Edward Sypniewski
Jul 9, 2004·Orthopedics·Charles Marc Samama
Sep 25, 2007·The Annals of Thoracic Surgery·Wulf DietrichAnna-Laure Boulesteix
Aug 30, 2011·The Annals of Thoracic Surgery·Nicole S WilderRichard G Ohye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.