Incidence of hypertriglyceridemia in critically ill neonates receiving lipid injectable emulsions in glass versus plastic containers: a retrospective analysis

The Journal of Pediatrics
Camilia R MartinDavid F Driscoll

Abstract

To evaluate plasma clearance of lipid injectable emulsions packaged in either glass or plastic containers in neonates from 2 7-month periods, 1 year apart. Clinical records from June 1 to December 31, 2003 (glass [G] period) and the same months in 2004 (plastic [P] period) were assessed. Neonates who received lipid injectable emulsions were studied. Lipid container (glass vs plastic) was the independent variable. Of the 197 patients studied, 122 (G, 50/81; P, 72/116) had evaluable triglyceride (TG) levels, for an overall rate of 62%. Only birth weight (G, 1.09 +/- 0.32 kg vs P, 1.23 +/- .45 kg) and birth length (G, 36.4 +/- 3.5 cm vs P, 37.9 +/- 3.5 cm) were significantly different between the 2 groups (P = .047 and .028, respectively). There were no differences in the day of life on which lipid injection was started, the lipid dose, or the timing of TG measurements. The incidence of hypertriglyceridemia was significantly higher in the P period (G, 3/50 vs P, 19/72; P = .004). Administration of the same lipid formulation in plastic bags compared with glass containers is associated with higher rates of hypertriglyceridemia. The poorer clearance of lipids could be due to a higher proportion of large-diameter fat globules in plast...Continue Reading

References

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Citations

Jan 1, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·T A StavroudisM R Miller
Mar 31, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ruben G J VisschersWim G van Gemert
Apr 19, 2015·Lipids in Health and Disease·Kevin A HarveyRafat A Siddiqui
Oct 14, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·David F DriscollB R Bistrian
Jun 28, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·David F DriscollBerthold Koletzko
Jul 17, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Mark G Klang
Aug 19, 2008·Nutrition·Thomas GonyonJean-Luc Trouilly
May 15, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·David F DriscollBruce R Bistrian
Oct 21, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Gil Hardy, Marko Puzovic
Sep 1, 2017·European Journal of Hospital Pharmacy. Science and Practice·Franziska GersondeThomas Kunze
Oct 28, 2021·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·M Petrea CoberUNKNOWN ASPEN Parenteral Nutrition Safety Committee

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