PMID: 6404950May 1, 1983Paper

Incidence of infection with hepatitis B virus in 56 patients with haemophilia A 1971-1979

Journal of Clinical Pathology
M L StirlingC A Ludlam

Abstract

During each of the four-year periods 1971-1975 and 1975-1979, the annual incidence of hepatitis B infection has been assessed in 56 patients with haemophilia A by measuring plasma HBsAg, anti-HBs and anti-HBc levels. Infection rates of 7% and 9.5% per annum respectively were observed for each four-year period despite the screening of individual blood donations for HBsAg by techniques up to the sensitivity of reversed passive haemagglutination. The highest incidence of seroconversion was amongst severe haemophiliacs many of whom had received treatment predominantly with cryoprecipitate. Of the 16 patients in whom serological evidence of hepatitis B infection was obtained only one had an accompanying clinical episode of hepatitis. We conclude that haemophiliacs are still at high risk of infection by hepatitis B virus despite the screening of individual blood donors for HBsAg.

References

May 26, 1979·Lancet·K N Tsiquaye, A J Zuckerman
Jul 17, 1982·Lancet·K A RickardJ Hodgson
Oct 1, 1980·Digestive Diseases and Sciences·U HasibaS S Shapiro
Jan 1, 1981·Journal of Clinical Pathology·M L StirlingI W Percy-Robb

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Citations

Nov 1, 1986·Journal of Virological Methods·R A Brown, B S Combridge
Mar 29, 2001·Transfusion·J M SoucieUNKNOWN Hemophilia Surveillance System Project Investigators
Jan 1, 1990·Vox Sanguinis·M D WilliamsF G Hill
Sep 1, 1985·Pediatric Annals·G Karayalcin
Jul 1, 1988·Journal of Medical Virology·M D WilliamsF G Hill
Dec 1, 1993·Blood Reviews·M Makris, F E Preston
May 26, 2006·Pediatric Blood & Cancer·Leonard A Valentino, Veeral M Oza
Oct 1, 1996·Haemophilia : the Official Journal of the World Federation of Hemophilia·H G WatsonP Simmonds
Dec 30, 2014·Orvosi hetilap·Márta MarschalkóSarolta Kárpáti
Jan 1, 1984·Scandinavian Journal of Haematology. Supplementum·M Colombo, M G Rumi
Sep 1, 1996·Transfusion·T J LynchJ S Finlayson

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