Incidence of infectious complications associated with the use of histamine2-receptor antagonists in critically ill trauma patients

Annals of Surgery
G E O'KeefeR V Maier

Abstract

To determine the impact of histamine2 (H2)-receptor antagonist use on the occurrence of infectious complications in severely injured patients. Some previous studies suggest an increased risk of nosocomial pneumonia associated with the use of H2-receptor blockade in critically ill patients, but other investigations suggest an immune-enhancing effect of H2-receptor antagonists. The purpose of this study was to determine whether H2-receptor antagonist use affects the overall incidence of infectious complications. Patients enrolled in a randomized trial comparing ranitidine with sucralfate for gastritis prophylaxis were examined for all infectious complications during their hospitalization. Data on the occurrence of pneumonia were prospectively collected, and other infectious complications were retrospectively obtained from the medical record. The relative risk of infectious complications associated with ranitidine use and total infectious complications were analyzed. Of 98 patients included, the charts of 96 were available for review. Sucralfate was given to 47, and 49 received ranitidine. Demographic factors were similar between the groups. Ranitidine use was associated with a 1.5-fold increased risk of developing any infectious ...Continue Reading

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Citations

May 1, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ligeng DuanJ W Alexander
Oct 12, 2001·Journal of Physiology, Paris·D Stancic-RokotovA Boban-Blagaic
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Oct 11, 2005·Critical Care Medicine·Nasia SafdarSanjay Saint
Dec 22, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Chun-Sick EomKang-Sook Lee
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Jun 14, 2001·Best Practice & Research. Clinical Gastroenterology·M Tryba
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Apr 1, 2017·Clinical Drug Investigation·Leon Fisher, Alexander Fisher
Mar 10, 2001·The American Journal of Gastroenterology·J M SchwartzG B McDonald
Sep 26, 2011·World Journal of Methodology·Chun-Sick Eom, Sang-Soo Lee
Jun 5, 2018·The Cochrane Database of Systematic Reviews·Ingrid ToewsJoerg J Meerpohl
Jul 19, 2011·Critical Care Medicine·Wilhelmina G MelsenMarc J M Bonten
Oct 13, 2006·Journal of Pediatric Gastroenterology and Nutrition·Joel R Rosh, Eric Hassall
May 3, 2006·Pediatrics·Roberto Berni CananiUNKNOWN Working Group on Intestinal Infections of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGEN

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