Incidence of Intermediate-stage Age-related Macular Degeneration in Patients With Acquired Immunodeficiency Syndrome

American Journal of Ophthalmology
Douglas A JabsPeter W Hunt

Abstract

To evaluate the incidence of intermediate-stage age-related macular degeneration (AMD) in patients with acquired immunodeficiency syndrome (AIDS). Cohort study. Patients enrolled in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) underwent 5- and 10-year follow-up retinal photographs. Intermediate-stage AMD (AREDS stage 3) was determined from these photographs by graders at a centralized Reading Center, using the Age-Related Eye Disease Study-2 grading system. The incidence of AMD in LSOCA was compared with that in the Multi-Ethnic Study of Atherosclerosis (MESA), a Human Immunodeficiency Virus (HIV)-uninfected cohort, which used a similar photographic methodology. The incidence of AMD in LSOCA was 0.65/100 person-years (PY). In a multivariate analysis the only significant risk factor for AMD in LSOCA was smoking; the relative risk vs never-smokers was 3.4 for former smokers (95% confidence interval [CI] 1.3, 9.5; P = .02) and 3.3 for current smokers (95% CI 1.1, 9.7; P = .03). Compared with the MESA cohort, the race/ethnicity- and sex-adjusted risk of AMD in LSOCA was 1.75 (95% CI 1.16, 2.64; P = .008), despite the fact that the mean age of the MESA cohort was 17 years greater than the LSOCA cohort (61 ± 9 y...Continue Reading

References

Dec 1, 1991·Statistics in Medicine·D G Altman
Apr 14, 2004·Archives of Ophthalmology·Nathan CongdonUNKNOWN Eye Diseases Prevalence Research Group
Nov 16, 2005·Archives of Ophthalmology·Matthew D DavisUNKNOWN Age-Related Eye Disease Study Group
Nov 16, 2005·Archives of Ophthalmology·Frederick L FerrisUNKNOWN Age-Related Eye Disease Study (AREDS) Research Group
Jan 11, 2007·Ophthalmology·Douglas A JabsUNKNOWN Studies of the Ocular Complications of AIDS Research Group
Jan 18, 2007·Annals of Internal Medicine·Nicolai LohseNiels Obel
Jan 30, 2007·Ophthalmology·Douglas A JabsUNKNOWN Studies of the Ocular Complications of AIDS Research Group
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert C KaplanStephen J Gange
Apr 19, 2008·Investigative Ophthalmology & Visual Science·Larry D HubbardUNKNOWN Age-Related Eye Disease 2 Research Group
Nov 26, 2010·Annual Review of Medicine·Steven G Deeks
Feb 9, 2012·American Journal of Ophthalmology·Elizabeth A SugarUNKNOWN Studies of the Ocular Complications of AIDS Research Group
Jul 21, 2012·Investigative Ophthalmology & Visual Science·Yara T E LechanteurCarel B Hoyng
Jan 22, 2013·Ophthalmology·Frederick L FerrisUNKNOWN Beckman Initiative for Macular Research Classification Committee
Feb 9, 2013·JAMA Ophthalmology·Vinod P MittaDebra A Schaumberg
Apr 27, 2013·Investigative Ophthalmology & Visual Science·Ronald P DanisUNKNOWN AREDS2 Study Group
Oct 26, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sophia PathaiKevin P High
Apr 24, 2014·The Journal of Infectious Diseases·Peter W HuntMichael M Lederman
Jul 25, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Khaled NassarSwaantje Grisanti
Mar 15, 2015·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Studies of the Ocular Complications of AIDS Research Group

❮ Previous
Next ❯

Citations

Oct 20, 2017·Current Infectious Disease Reports·Michael W Stewart
Jan 18, 2019·Investigative Ophthalmology & Visual Science·Carsten FaberMogens Holst Nissen
May 21, 2019·Investigative Ophthalmology & Visual Science·Douglas A JabsPeter W Hunt
May 24, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Berkay AkmazTuna Demirdal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.