PMID: 11317082Apr 24, 2001Paper

Incidence of invasive cervical cancer in a cohort of HIV-seropositive women before and after the introduction of highly active antiretroviral therapy

Journal of Acquired Immune Deficiency Syndromes : JAIDS
M DorrucciItalian HIV-Seroconversion Study

Abstract

To assess whether the incidence of invasive cervical cancer (ICC) has changed as a result of highly active antiretroviral therapy (HAART), we conducted a prospective cohort study on the incidence of ICC before and after the introduction of HAART among Italian women with a known duration of HIV infection. We estimated the incidence per 1000 person years of ICC as a first AIDS-defining disease for the periods 1981 through 1991, 1992 through 1995, and 1996 through 1998. We also estimated the incidence of other first AIDS-defining diseases. Kaplan-Meier and Cox models were applied to compare the periods 1981 through 1995 and 1996 through 1998 in terms of cumulative incidence and relative hazards (RHs). The analysis included 483 women (median follow-up: 7 years). In the period 1981 through 1995, a trend of increase was observed in the incidence of ICC and other AIDS-defining diseases; this trend has continued only for ICC, whereas the incidence of other AIDS-defining diseases has decreased since 1996. Compared with 1981 through 1995, the RH of ICC for 1996 through 1998 was 7.41 (95% confidence interval [CI]: 1.21--45.44); when adjusting for age at HIV seroconversion, the RH decreased to 4.75 (95% CI: 0.80--28.24). It remains to be d...Continue Reading

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Citations

Aug 25, 2010·Immunologic Research·Tammy M Rickabaugh, Beth D Jamieson
Mar 8, 2002·Clinical and Experimental Immunology·Byeong-Sun ChoiJoo-Shil Lee
Jun 13, 2003·The Journal of the Association of Nurses in AIDS Care : JANAC·Priscilla D Abercrombie
Mar 22, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·Z M Chirenje
Dec 17, 2008·Women's Health·Amrita Krishnan, Alexandra M Levine
Sep 26, 2015·Mechanisms of Ageing and Development·Rita B Effros
Oct 9, 2014·Journal of Infection and Public Health·Ricardo Ney Oliveira CobucciAna Katherine Gonçalves
Jun 5, 2012·Enfermedades infecciosas y microbiología clínica·M A Eulalia Valencia Ortega
Mar 26, 2015·PloS One·Tammy M RickabaughBeth D Jamieson
Apr 26, 2017·International Journal of Cancer. Journal International Du Cancer·Eliane RohnerJulia Bohlius
Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Annarosa Del MistroLuigi Chieco-Bianchi
Jun 29, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nancy A HessolUNKNOWN WIHS Collaborative Study Group
Nov 2, 2001·AIDS Patient Care and STDs·J Laurence
Sep 1, 2007·Current Opinion in Oncology·Michael J Silverberg, Donald I Abrams
Dec 24, 2003·The Cancer Journal·Nicholas C Lambrou, Leo B Twiggs
Feb 19, 2009·British Journal of Cancer·L Dal MasoUNKNOWN Cancer and AIDS Registries Linkage (CARL) Study

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