Incidence of metallo-beta-lactamase-producing Klebsiella pneumoniae isolates from hospital setting in Pakistan

International Microbiology : the Official Journal of the Spanish Society for Microbiology
Aqsa HumayunHabib Bokhari

Abstract

The aim of this study was monitoring and surveillance in different wards of the PIMS hospital, Islamabad, to understand emerging challenges of antibiotic resistance in particular association with most virulent serotypes of Klebsiella pneumoniae. The study was conducted during March 2015 to September 2015. The study showed that rate of isolation of K. pneumoniae was 37% (103 positives out of a total of 277 clinical samples) and 7.7% (8) were phenotypically and genotypically confirmed to be metallo-β-lactamase resistant (carbapenem resistant) and all of them were multidrug resistant (MDR). These carbapenem-resistant isolates were isolated from blood, endotracheal tubes, and pus. Molecular screening for the presence of integrons indicated that distribution of class I integrons (87.5% of carbapenem-resistant K. pneumoniae isolates) was higher than class II integrons (1.25%) among given isolates. The study indicated that exposure of metallo-beta-lactamase-producing strains through hospitalizations increases the chances of spread of MDR pathogens. There is an urgent need for effective surveillance and monitoring strategies to control the spread of extremely resistant K. pneumoniae implicated in nosocomial infections leading to the in...Continue Reading

References

Oct 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·D J Tipper, J L Strominger
Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A A Medeiros
Nov 14, 1997·Trends in Microbiology·G D Recchia, R M Hall
Sep 27, 2000·FEMS Microbiology Letters·A W BrownD J Platt
May 22, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Elizabeth MathaiGöran Kronvall
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hervé TettelinClaire M Fraser
Aug 25, 2006·Journal of Clinical Microbiology·Maria Silvana AlvesBeatriz Meurer Moreira
Dec 23, 2006·The Journal of Antimicrobial Chemotherapy·Matthew J EllingtonNeil Woodford
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Oct 8, 2014·BMC Research Notes·Ram Hari PokhrelChanwit Tribuddharat
May 20, 2015·Emerging Infectious Diseases·Mitchell W PeseskyGautam Dantas
Oct 22, 2015·Annals of Clinical Microbiology and Antimicrobials·Yang DengGuangchao Yu
Apr 27, 2015·Acute Medicine & Surgery·Rumi OkazakiMasami Murakami

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.