PMID: 8971884Dec 1, 1996Paper

Incidence of microalbuminuria in children with pyelonephritic scarring

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
J KarlénA Aperia

Abstract

There is experimental evidence that loss of renal parenchyma results in hyperfiltration in the remnant glomeruli followed by development of glomerulosclerosis. Microalbuminuria, i.e., a urinary albumin excretion rate of 20-200 micrograms/min, is considered to be an early predictor of diabetic glomerulosclerosis. Hypothetically, increased urinary albumin excretion in patients with pyelonephritic scarring may also indicate glomerulosclerosis, with risk for future deterioration of renal function. This study was performed to determine the incidence of increased albumin excretion in children with mild to moderate pyelonephritic scarring, and to relate the information to glomerular filtration rate (GFR; clearance of inulin) and effective renal plasma flow (clearance of para-aminohippuric acid), as well as to the degree of scarring. The functional investigations were performed under water diuresis. Fifty-seven children, aged 1.7-17.9 years, with pyelonephritic renal scarring were included in the study. Nine young healthy adults were used as controls. The GFR was significantly lower in the children with pyelonephritic scarring than in the controls (median 93 ml/min per 1.73 m2, range 48-133 vs. 111 ml/min per 1.73 m2, range 89-121, P <...Continue Reading

Citations

May 8, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tej K Mattoo
Sep 12, 2007·International Urology and Nephrology·Hüray IslekelSalih Kavukcu
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francois CachatEric Girardin
Nov 26, 2014·Expert Review of Anti-infective Therapy·Brian BecknellJohn David Spencer
Sep 8, 2011·Advances in Chronic Kidney Disease·Tej K Mattoo
Aug 3, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Shigeru SatohTomonori Habuchi
Aug 8, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ana MalvarBrad H Rovin
Oct 17, 2017·International Journal of Environmental Research and Public Health·Erick Sierra-DiazHernandez-Flores Georgina
Dec 15, 2017·International Journal of Environmental Research and Public Health·Felipe Lozano-KastenUNKNOWN Research Group on Social and Environmental Determinants in Childhood
Oct 21, 2016·American Journal of Physiology. Renal Physiology·Birong LiBrian Becknell
Dec 31, 2010·Korean journal of pediatrics·Byung Ok KwakKyo Sun Kim

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