Incidence of Mild Cognitive Impairment and Dementia in Parkinson's Disease: The Parkinson's Disease Cognitive Impairment Study

Frontiers in Aging Neuroscience
Alessandra NicolettiRoberto Monastero

Abstract

Background: Cognitive impairment in Parkinson's disease (PD) includes a spectrum varying from Mild Cognitive Impairment (PD-MCI) to PD Dementia (PDD). The main aim of the present study is to evaluate the incidence of PD-MCI, its rate of progression to dementia, and to identify demographic and clinical characteristics which predict cognitive impairment in PD patients. Methods: PD patients from a large hospital-based cohort who underwent at least two comprehensive neuropsychological evaluations were retrospectively enrolled in the study. PD-MCI and PDD were diagnosed according to the Movement Disorder Society criteria. Incidence rates of PD-MCI and PDD were estimated. Clinical and demographic factors predicting PD-MCI and dementia were evaluated using Cox proportional hazard model. Results: Out of 139 enrolled PD patients, 84 were classified with normal cognition (PD-NC), while 55 (39.6%) fulfilled the diagnosis of PD-MCI at baseline. At follow-up (mean follow-up 23.5 ± 10.3 months) 28 (33.3%) of the 84 PD-NC at baseline developed MCI and 4 (4.8%) converted to PDD. The incidence rate of PD-MCI was 184.0/1000 pyar (95% CI 124.7-262.3). At multivariate analysis a negative association between education and MCI development at follow-...Continue Reading

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Citations

Nov 20, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Chiara BaianoGabriella Santangelo
Mar 27, 2020·Neural Regeneration Research·Davide Maria CammisuliUbaldo Bonuccelli
Nov 30, 2019·Frontiers in Aging Neuroscience·Davide Maria CammisuliCarlo Pruneti
Apr 21, 2020·Journal of Parkinson's Disease·Jessie De RoyJean-François Gagnon
Aug 28, 2020·Frontiers in Neurology·Ana Simon-GozalboPablo Martinez-Martin
Oct 6, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhen-Yu ShuMinming Zhang
Oct 29, 2020·Aging & Mental Health·Gabriella SantangeloCarmine Vitale
Oct 30, 2020·Frontiers in Neurology·Cristina RascunàAlessandra Nicoletti
Feb 28, 2021·Scientific Reports·Kyoungwon BaikSuk Yun Kang
Mar 16, 2021·Journal of Alzheimer's Disease : JAD·Antonina LucaMario Zappia
May 25, 2021·Journal of Parkinson's Disease·Rachael A LawsonUNKNOWN ICICLE-PD study group
Jul 3, 2021·Behavioral Sciences·Ángela Milán-TomásMaría Cruz Rodríguez-Oroz
Jul 3, 2021·Brain Sciences·Paola FeracoRoberto Monastero
Jul 27, 2021·Annals of Clinical and Translational Neurology·Hailing LiuQing Wang
Jan 14, 2022·Journal of Neural Transmission·Antonina LucaAlessandra Nicoletti

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