Incidence of muscle relaxant use in relation to diagnosis of Parkinson's disease.

International Journal of Clinical Pharmacy
Anne PaakinahoMiia Tiihonen

Abstract

Background Parkinson's disease is the second most common neurodegenerative disorder. Motor and non-motor symptoms seem to precede the diagnosis of Parkinson's disease. Objective To evaluate the incidence of muscle relaxant use in community-dwelling persons with and without Parkinson's disease from 4 years before to 4 years after the diagnosis of Parkinson's disease. Method Nationwide register-based cohort included all community-dwelling Finnish persons who received reimbursement of Parkinson's disease drugs between 2000 and 2015 (N = 17,450) and comparison persons without Parkinson's disease who were matched for age, gender and region of residence (N = 122,694). Data on muscle relaxant use during 1995-2016 were collected from the Prescription Register. Results The incidence of muscle relaxant use was higher among persons with Parkinson's disease in comparison to persons without Parkinson's disease from 3 years before the diagnosis until 6 months after the diagnosis. The largest difference in incidence rates was observed at the time of the diagnosis (incidence rate ratio = 2.04, 95% confidence interval = 1.81-2.30). Tizanidine was the most frequently initiated muscle relaxant. Conclusions The incidence of muscle relaxant use sta...Continue Reading

References

Jan 9, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Dominique TwelvesCarl Counsell
Jun 5, 2003·American Journal of Epidemiology·Stephen K Van Den EedenLorene M Nelson
Aug 18, 2012·Scandinavian Journal of Public Health·Reijo Sund
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Feb 6, 2017·Journal of Neural Transmission·Ole-Bjørn Tysnes, Anette Storstein

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Citations

Jan 7, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Tomi KuusimäkiValtteri Kaasinen

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