Incidence of Mycobacterium avium subspecies paratuberculosis in a population-based cohort of patients with Crohn's disease and control subjects

The American Journal of Gastroenterology
Robert W BentleyRebecca L Roberts

Abstract

To define the incidence of Mycobacterium avium subspecies paratuberculosis (MAP) in patients with Crohn's disease (CD) and in control subjects. Blood samples from 361 CD patients from a previously described population-based inflammatory bowel disease (IBD) cohort and 200 blood donor controls, of known NOD2 genotype, were screened by PCR for MAP-specific IS900 DNA. These results were correlated with NOD2 genotype. The PCR assay was capable of detecting 20 fg of purified MAP DNA, equivalent to roughly 100 MAP cells/mL of blood. MAP-specific IS900 DNA was detected in 33.8% of CD cases and 21.5% of controls (OR 1.86, 95% CI 1.247-2.785, P= 0.002). All study participants were genotyped for the NOD2 mutations 2104C>T (R702W), 2722G>C (G908R), and 3020insC (1007fs). Carriage of one or two NOD2 mutations was not associated with a significantly higher risk of CD (OR 0.75, 95% CI 0.465-1.207, P= 0.234). No significant association was seen in the CD cohort for carriage of one or two NOD2 mutations and MAP status (OR 0.883, 95% CI 0.494-1.579, P= 0.675). Screening peripheral blood using IS900 PCR indicated that MAP DNA could be detected in a significant proportion of CD cases from a large population-based cohort, and also, in control subje...Continue Reading

References

Jun 1, 1995·Trends in Genetics : TIG·A Pospiech, B Neumann
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D SchwartzS A Naser
Apr 10, 2002·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Sung G KimDonald A Lein
Jan 7, 2003·The Journal of Biological Chemistry·Naohiro InoharaGabriel Nuñez
Jan 16, 2003·The Journal of Biological Chemistry·Stephen E GirardinPhilippe J Sansonetti
Dec 3, 2003·Trends in Immunology·Stephen E GirardinPhilippe J Sansonetti
Aug 4, 2004·Lancet·Robert J Greenstein, Michael T Collins
Nov 6, 2004·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Rebecca L RobertsMartin A Kennedy
Dec 2, 2004·The American Journal of Gastroenterology·Michael EconomouJohn P A Ioannidis
Oct 7, 2005·Journal of Clinical Microbiology·Leonardo A SechiStefania Zanetti
Oct 3, 2006·Inflammatory Bowel Diseases·Richard B GearryMurray L Barclay
Feb 24, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R ClancyA Wettstein
Jun 16, 2007·Gastroenterology·Warwick SelbyUNKNOWN Antibiotics in Crohn's Disease Study Group
Jun 16, 2007·Gastroenterology·Laurent Peyrin-BirouletJean-Frédéric Colombel

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Citations

Apr 9, 2009·Current Opinion in Infectious Diseases·Christopher D Packey, R Balfour Sartor
Aug 15, 2012·Infection and Immunity·Dayle A KeownJacqueline I Keenan
Dec 4, 2010·World Journal of Gastroenterology : WJG·Lucy C StewartRobert W Bentley
Jan 17, 2012·Critical Reviews in Microbiology·Rodrick J ChiodiniRichard W McCallum
Mar 3, 2017·The Journal of Dairy Research·Ahmed M SallamBrian W Kirkpatrick
Jul 8, 2011·Digestive Diseases·Philippe Marteau, Ulriikka Chaput
Jan 29, 2010·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Govind K Makharia, Urvashi B Singh
Oct 29, 2010·Gut and Liver·Melissa FriswellJonathan Rhodes
Oct 26, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Miloslav Kverka, Helena Tlaskalova-Hogenova
Oct 4, 2014·World Journal of Gastroenterology : WJG·Elisa LiveraniAndrea Belluzzi
Jul 26, 2017·World Journal of Gastroenterology : WJG·Lukas BajerPavel Drastich
Mar 8, 2011·Journal of Food Protection·C O GillW J Meadus
Oct 1, 2011·Tropical Animal Health and Production·Sulficar Shamsudeen RawtherKrishna Kripa Narayanan Nimisha

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