Incidence of Neonatal Neutropenia and Leukopenia After In Utero Exposure to Chemotherapy for Maternal Cancer

American Journal of Clinical Oncology
Maria La NasaElyce Cardonick

Abstract

The main purpose of this article was to report the incidence of neonatal neutropenia or leukopenia after chemotherapy exposure during pregnancy according to the time elapsed between treatment during pregnancy and birth. A single study reports 33% of infants exposed to chemotherapy within the last month of pregnancy are born with neutropenia, which can place the newborn at risk for nosocomial infections. On the basis of this report, chemotherapy is typically stopped by 34 weeks of pregnancy to avoid maternal or neonatal myelosuppression at delivery. Such a pause in treatment may affect maternal health. Determining the true incidence of neutropenia after chemotherapy in relation to the time of this lapse in treatment is important to support this practice. Complete blood counts are collected for newborn whose mothers were treated for cancer during pregnancy and enrolled in the Cancer and Pregnancy Registry. Neutropenia was defined as absolute neutrophil count<1000 mm3 and leukopenia was defined as white blood cells <5000 cells/μL. Incidence of neutropenia was calculated according to the time elapsed from last chemotherapy treatment until birth. Fisher's exact test is used to determine if neutropenia or leukopenia is related to the...Continue Reading

References

Jan 1, 1988·Medical and Pediatric Oncology·A Avilés, J Niz
Jul 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E E ReynosoM A Baker
Nov 22, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R M PeresL Schüler-Faccini
Oct 31, 2003·American Journal of Obstetrics and Gynecology·Lloyd H SmithRosemary Cress
Feb 19, 2010·The Cancer Journal·Elyce CardonickAniqa Usmani
Mar 14, 2012·Archives of Gynecology and Obstetrics·El-Said Abdel-HadyMohammed Attia El-Bayoumi
Dec 11, 2013·Current Opinion in Hematology·Akhil Maheshwari
Sep 29, 2015·The New England Journal of Medicine·Frédéric AmantUNKNOWN International Network on Cancer, Infertility, and Pregnancy (INCIP)
Nov 11, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Siew-Fei Ngu, Hextan Y S Ngan

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Citations

Feb 7, 2020·Current Oncology Reports·Charlotte MaggenUNKNOWN International Network on Cancer, Infertility and Pregnancy (INCIP)
Oct 1, 2019·American Journal of Clinical Oncology·Valentina A DegennaroSara De Carolis
Sep 19, 2020·Cancer Management and Research·Liqin MaHaixia Wu
Mar 3, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Vera WoltersFrédéric Amant

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