Incidence of nephrogenic systemic fibrosis at Chinese PLA General Hospital

Journal of Magnetic Resonance Imaging : JMRI
Zhitong ZouHengjin Li

Abstract

Magnetic resonance imaging (MRI), dermatology, and dermatopathology records were searched to determine the incidence of nephrogenic systemic fibrosis (NSF) at a large military hospital in China. Over the past 3.7 years, gadolinium-based contrast agent (GBCA)-enhanced MRI was performed with Gd-DTPA (n = 28,680) or MultiHance (n = 635) typically at slightly more than a standard dose, as most patients received a unit dose, 15 mL or 20 mL instead of a weight-based dose. This included 118 renal failure patients with estimated glomerular filtration rate (eGFR) less than 30 mL/min and 33 patients on chronic hemodialysis. Despite a diligent search involving rereview of histopathological sections in similarly diagnosed cases, there was no evidence that any patient developed nephrogenic systemic fibrosis. For the renal failure and hemodialysis patients, there were no clinical notes of unexplained rashes within 3 months following GBCA. The incidence of NSF in Chinese People Liberation Army General Hospital using gadolinium (Gd) in 29,315 patients, 151 with severe renal failure or hemodialysis, is thus far undetectable. J. Magn. Reson. Imaging 2009;30:1309-1312. (c) 2009 Wiley-Liss, Inc.

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May 17, 2011·Indian Journal of Dermatology·Zhitong Zou, Lin Ma
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·Tim Leiner, Walter Kucharczyk
Oct 20, 2011·Scandinavian Journal of Urology and Nephrology·Alaa AlhadadPeter Leander
Nov 19, 2011·JACC. Cardiovascular Imaging·Zhitong ZouMartin R Prince
Oct 4, 2016·Magnetic Resonance Imaging·Joana RamalhoRichard C Semelka
Jun 23, 2020·Annals of Internal Medicine·Joseph LunyeraKaren M Goldstein

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