Incidence of non-pulmonary cancer and lung cancer by amount of emphysema and airway wall thickness: a community-based cohort

The European Respiratory Journal
Ane Aamli GagnatP S Bakke

Abstract

There is limited knowledge about the prognostic value of quantitative computed tomography (CT) measures of emphysema and airway wall thickness in cancer.The aim of this study was to investigate if using CT to quantitatively assess the amount of emphysema and airway wall thickness independently predicts the subsequent incidence of non-pulmonary cancer and lung cancer.In the GenKOLS study of 2003-2005, 947 ever-smokers performed spirometry and underwent CT examination. The main predictors were the amount of emphysema measured by the percentage of low attenuation areas (%LAA) on CT and standardised measures of airway wall thickness (AWT-PI10). Cancer data from 2003-2013 were obtained from the Norwegian Cancer Register. The hazard ratio associated with emphysema and airway wall thickness was assessed using Cox proportional hazards regression for cancer diagnoses.During 10 years of follow-up, non-pulmonary cancer was diagnosed in 11% of the subjects with LAA <3%, in 19% of subjects with LAA 3-10%, and in 17% of subjects with LAA ≥10%. Corresponding numbers for lung cancer were 2%, 3% and 11%, respectively. After adjustment, the baseline amount of emphysema remained a significant predictor of the incidence of non-pulmonary cancer and...Continue Reading

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Jul 26, 2019·PloS One·Jessica GonzálezJavier J Zulueta
Dec 7, 2017·Current Opinion in Pulmonary Medicine·Abhishek BiswasErik E Folch
Sep 19, 2020·European Clinical Respiratory Journal·Ane Aamli GagnatRune Nielsen
May 28, 2019·Respiratory Medicine·Gunnar R HusebøTomas Eagan
Jul 21, 2021·International Journal of Molecular Sciences·Kaschin Jamal JameelJürgen Knobloch

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