Incidence of pancreatitis in HIV-infected patients receiving nucleoside reverse transcriptase inhibitor drugs

AIDS
R D MooreR E Chaisson

Abstract

Pancreatitis is a known adverse effect of the nucleoside reverse transcriptase inhibitors, particularly didanosine. Hydroxyurea has been used to potentiate the antiviral efficacy of didanosine, but recently there has been concern that severe and even fatal pancreatitis may be more likely to occur when hydroxyurea is used in combination with didanosine. We investigated the incidence of pancreatitis in patients using nucleoside analogues with or without hydroxyurea. Data were obtained from patients followed longitudinally on the Johns Hopkins HIV Clinic. Incidence rates of pancreatitis were calculated for each antiretroviral regimen that included zidovudine, stavudine, didanosine (+ hydroxyurea), and didanosine + stavudine (+ hydroxyurea). Poisson regression was used to compare the relative rate of pancreatitis for each regimen adjusting for other covariates. A total of 2613 patients received at least one of the nucleoside reverse transcriptase inhibitor-containing regimens. There were 33 cases of pancreatitis. The crude incidence rate of pancreatitis ranged from 0.18 cases per 100 person-years on therapy for zidovudine to 6.25 cases per 100 person-years for didanosine + hydroxyurea. Compared to didanosine alone, and adjusting fo...Continue Reading

References

Dec 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A SchindzielorzL Smaldone
Feb 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I M Pike, C Nicaise
May 20, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·R D Moore
Jul 25, 2000·Annals of Internal Medicine·K D MillerJ A Kovacs

❮ Previous
Next ❯

Citations

Oct 13, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Hartmann
Nov 28, 2001·Current Infectious Disease Reports·Cecilia M. Shikuma, Bruce Shiramizu
May 23, 2002·Current Infectious Disease Reports·Julio S.G. Montaner, Marianne Harris
Sep 19, 2003·Current Infectious Disease Reports·Alice K. Pau
Aug 9, 2008·Current Infectious Disease Reports·Katherine A Belden, Kathleen E Squires
Jun 5, 2013·Asian Pacific Journal of Tropical Biomedicine·Gordana Dragovic
Dec 13, 2005·Sexual Health·Catherine L CherrySteven L Wesselingh
May 27, 2005·Journal of Psychoactive Drugs·Jeffrey T ParsonsJoseph P Carbonari
May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I Sereti, H C Lane
Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas P GiordanoFehmida Visnegarwala
Nov 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara McGovernIoana Bica
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ramnath SubbaramanNagalingeswaran Kumarasamy
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bruce R SchackmanKenneth A Freedberg
Jun 21, 2003·AIDS Patient Care and STDs·Charles HicksChristine Wanke
Jun 10, 2005·AIDS Research and Human Retroviruses·Franco LoriJ Lisziewicz
Sep 18, 2002·The Journal of Perinatal & Neonatal Nursing·Maureen Shannon
Jun 4, 2008·AIDS·Neil H ShearElizabeth J Phillips
Jan 27, 2005·HIV Medicine·D A PriceM H Snow
Jun 13, 2001·Sexually Transmitted Infections·A J White
Jun 29, 2013·Critical Care : the Official Journal of the Critical Care Forum·Putul Sarkar, Husham F Rasheed
Jun 10, 2011·Proceedings of the American Thoracic Society·Kathleen M AkgünKristina Crothers
Feb 12, 2009·Pharmacogenomics·Pek Y LumEric E Schadt
Aug 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer N BlanchardJ Tyler Lonergan
Feb 22, 2008·Digestive Diseases and Sciences·Arvind J TrindadeMichelle K Kim
Oct 18, 2007·Expert Opinion on Pharmacotherapy·Gerrit Schreij, Robert Janknegt
Jun 20, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Julianna LisziewiczFranco Lori
Apr 24, 2010·Emergency Medicine Clinics of North America·Daniel M LugassyLewis S Nelson
Jun 24, 2008·The Medical Clinics of North America·Mitchell S Cappell
Sep 14, 2012·Alimentary Pharmacology & Therapeutics·J N L SchoutenH L A Janssen
Jan 9, 2004·Infectious Disease Clinics of North America·Sandra L PrestonGeorge L Drusano
Jun 6, 2015·La Revue de médecine interne·L ChebaneJ-L Montastruc
Apr 18, 2015·Trends in Molecular Medicine·Jay A Levy
Mar 4, 2008·BMC Medical Imaging·Millicent O ObajimiIsaac F Adewole
Sep 14, 2016·HLA : Immune Response Genetics·J SteinH Streeck

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.