PMID: 11320815Apr 26, 2001Paper

Incidence of potential transmitters of Creutzfeldt-Jakob disease. A study of a collective of potential cornea donors

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
T BredehornG I Duncker

Abstract

The prevalence of Creutzfeldt-Jakob disease (CJD) is 1.5 cases per million persons. In addition to familial and sporadic forms, fewer than 5% of cases are due to iatrogenic transmission. Corneal transplantation has clearly been implicated as the origin of CJD in four cases. We examined possible risks factors for corneal transplantation in material from 2545 deceased patients at the University Hospital of Halle. Two patients had died of CJD or slow virus disease. Also in the 109 identified as being at higher risk of CJD no organs or tissues were harvested. We strongly recommend that patients at higher risk group of CJD, patients dying of CNS diseases of unknown origin and cause, and patients dying in psychiatric clinics be excluded from donating organ and tissue.

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