Jan 1, 1977

Incidence of precancerous changes in the hormone-dependent organs of women with ovarian dysfunction

Voprosy onkologii
I A Manuilova, R A Frolova


The authors present the results of studies on the state of the endometrium and mammary glands in patients with three most frequently occurred forms of menstrual cycle disorders (185-with dysfunctional uterine bleeding, 104-with oligo-opsomenorrhea, 104-with secondary amenorrhea). It is found that disturbances in the ovarian hormonal function result in the development of hyperplastic processes in the endometrium in 62.2% of patients, and in the mammary gland--in 55.7%. In dysfunctional uterine bleeding hyperplastic processes develop mainly in the endometrium (94.5%), while mammary glands are more seldom involved in the pathological process (57.6%). In oligo-opsomenorrhea and secondary amenorrhea dishormonal affections more frequently occur in mammary glands (64.5% and 43.6% accordingly) compared with the endometrium, where dysplasia and atrophic changes prevail. The correction of the ovarian function disorders in due course leads to considerable reduction of the incidence of dyshormonal lesions in receptory organs, many of which should be considered as precancer.

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Mentioned in this Paper

Ovarian Diseases
Uterine Cancer
Epithelioid Hemangioma of Skin
Ventricular Dysfunction
Mammary Neoplasms, Human

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