Incidence of precancerous foci of mammary glands and growth rate of transplantable mammary cancers in sialoadenectomized mice

Journal of the National Cancer Institute
T InuiS Morii


Sialoadenectomies performed on 8-week-old female SHN and GR mice markedly reduced the numbers of precancerous and cancerous lesions in their mammary glands that had been mildly hypoplastic; the mice were necropsied when they were 30 weeks old. The success rate of the mammary cancer transplantation to isogenic male SHN or C3H mice was lower in the sialoadenectomized animals, and growth of the grafted tumors was delayed after gland removal. Some tumor development resumed in the hosts that received mouse epidermal growth factor after surgery. Therefore, we believe this growth factor may play a role in the multistage process of mouse mammary carcinogenesis.


Jan 1, 1993·Teratogenesis, Carcinogenesis, and Mutagenesis·D Vassilacopoulou, E S Boylan
Sep 1, 1993·Cancer Metastasis Reviews·K KhazaieR B Lichtner
Nov 1, 1990·Breast Cancer Research and Treatment·E KordonC Dosne Pasqualini
Sep 1, 1993·Bulletin of Mathematical Biology·S Michelson, J T Leith
Nov 1, 1995·Critical Reviews in Oncology/hematology·N ItoT Shirai
Jun 1, 1991·Environmental Health Perspectives·A M Malkinson
Jan 11, 1992·Journal of Cellular Biochemistry. Supplement·R J CoffeyW H Polk
May 3, 1996·Biochemical Pharmacology·D E Davies, S G Chamberlin

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