Incidence of primary liver cancer in American Indians and Alaska Natives, US, 1999-2009

Cancer Causes & Control : CCC
Stephanie C MelkonianMary C White

Abstract

To evaluate liver cancer incidence rates and risk factor correlations in non-Hispanic AI/AN populations for the years 1999-2009. We linked data from 51 central cancer registries with the Indian Health Service patient registration databases to improve identification of the AI/AN population. Analyses were restricted to non-Hispanic persons living in Contract Health Service Delivery Area counties. We compared age-adjusted liver cancer incidence rates (per 100,000) for AI/AN to white populations using rate ratios. Annual percent changes (APCs) and trends were estimated using joinpoint regression analyses. We evaluated correlations between regional liver cancer incidence rates and risk factors using Pearson correlation coefficients. AI/AN persons had higher liver cancer incidence rates than whites overall (11.5 versus 4.8, RR = 2.4, 95% CI 2.3-2.6). Rate ratios ranged from 1.6 (Southwest) to 3.4 (Northern Plains and Alaska). We observed an increasing trend among AI/AN persons (APC 1999-2009 = 5%). Rates of distant disease were higher in the AI/AN versus white population for all regions except Alaska. Alcohol use (r = 0.84) and obesity (r = 0.79) were correlated with liver cancer incidence by region. Findings highlight disparities in...Continue Reading

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Citations

Oct 14, 2019·Cancer Causes & Control : CCC·Maxwell SalvatoreRafael Meza
Aug 15, 2019·International Journal of Environmental Research and Public Health·Fang WangHao Li
Aug 3, 2020·The American Journal of Gastroenterology·Stephanie C MelkonianMary C White
Oct 3, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stephanie C MelkonianDavid K Espey
Jan 3, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nicole E RichAmit G Singal
Mar 20, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yvonne N FloresFolasade P May

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Software Mentioned

Joinpoint Regression Program
SAS
* Stat
LinkPlus
SEER

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