Abstract
Autoimmune hyperthyroidism may occur several months after radioiodine therapy (RIT) for functional thyroid autonomy. Exacerbation of pre-existing subclinical Graves' disease (GD) has been held responsible for this phenomenon. Determination of TSH receptor antibody using solubilised porcine epithelial cell membranes is insensitive and may have failed to diagnose GD in these patients before RIT. Following the introduction of a more sensitive assay, using the human TSH receptor as an antigen, it has been expected that the incidence of radiation-induced GD after RIT for functional thyroid autonomy will be reduced. In a first group of 1,428 patients treated between November 1993 and March 1997 (group I) we used the porcine TRAb assay to exclude GD, while in a second group comprising 1,408 patients treated between January 2000 and December 2001 (group II), GD was excluded using the human TRAb assay. A matched control group of 231 patients was derived from group II. In group I a total of 15 (1.05%) patients developed obvious or suspected radiation-induced GD, while in group II 17 (1.2%) did so; the interval until development of GD was 8.4 and 8.8 months, respectively, after RIT. Serum anti-thyroid peroxidase levels before RIT were ele...Continue Reading
Citations
Mar 31, 2006·Thyroid : Official Journal of the American Thyroid Association·Matthias SchmidtHarald Schicha
Jun 29, 2010·Thyroid : Official Journal of the American Thyroid Association·Gregory A Brent
Nov 27, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Aleksandar Z AleksićMiljan J Jović
Apr 27, 2010·Journal of Endocrinological Investigation·A ChiapporiG Pesce
Jul 19, 2011·Wiener klinische Wochenschrift·Hans-Jürgen Biersack, Kim Biermann
Sep 17, 2008·The American Journal of the Medical Sciences·Alessandro AntonelliEle Ferrannini
Nov 21, 2012·La Presse médicale·Jacques Orgiazzi
Jan 5, 2011·Annales d'endocrinologie·L GiovansiliM-L Herdan
Feb 11, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Robert Lloyd Segal, Sylvan Wallenstein
Dec 3, 2014·Autoimmunity Reviews·Alessandro AntonelliPoupak Fallahi
Dec 7, 2016·Nuklearmedizin. Nuclear Medicine·Markus DietleinMarkus Luster
Nov 16, 2017·Medicine·Guohua ShenAnren Kuang
Oct 27, 2017·Journal of Radiation Research·Yuji Nagayama
Jan 22, 2018·Journal of Endocrinological Investigation·C Roque, C A Vasconcelos
Jan 2, 2007·Nuclear Medicine Communications·Guido C HovensJohannes W Smit
Oct 5, 2013·Endocrine Reviews·Sandra M McLachlan, Basil Rapoport
Sep 11, 2012·Endocrine Reviews·Steen Joop Bonnema, Laszlo Hegedüs
Sep 6, 2019·International Journal of Radiation Biology·Andrew S RileyJohn Greenman
Apr 5, 2017·Frontiers in Endocrinology·Silvia Martina FerrariSalvatore Benvenga
Mar 21, 2018·Military Medical Research·Rasoul YahyapourMasoud Najafi
Mar 3, 2009·Nuclear Medicine Communications·Sang-Woo LeeInkyu Lee
Oct 10, 2020·Journal of Neural Transmission·Christoph ReinersShunichi Yamashita
Jun 19, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Vahab Fatourechi