Incidence of remission and relapse of proteinuria, end-stage kidney disease, mortality, and major outcomes in primary nephrotic syndrome: the Japan Nephrotic Syndrome Cohort Study (JNSCS).

Clinical and Experimental Nephrology
Ryohei YamamotoYoshitaka Isaka

Abstract

Despite recent advances in immunosuppressive therapy for patients with primary nephrotic syndrome, its effectiveness and safety have not been fully studied in recent nationwide real-world clinical data in Japan. A 5-year cohort study, the Japan Nephrotic Syndrome Cohort Study, enrolled 374 patients with primary nephrotic syndrome in 55 hospitals in Japan, including 155, 148, 38, and 33 patients with minimal change disease (MCD), membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS), and other glomerulonephritides, respectively. The incidence rates of remission and relapse of proteinuria, 50% and 100% increases in serum creatinine, end-stage kidney disease (ESKD), all-cause mortality, and other major adverse outcomes were compared among glomerulonephritides using the Log-rank test. Incidence of hospitalization for infection, the most common cause of mortality, was compared using a multivariable-adjusted Cox proportional hazard model. Immunosuppressive therapy was administered in 339 (90.6%) patients. The cumulative probabilities of complete remission within 3 years of the baseline visit was ≥ 0.75 in patients with MCD, MN, and FSGS (0.95, 0.77, and 0.79, respectively). Diabetes was the most common adverse events...Continue Reading

References

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Citations

Aug 8, 2020·Clinical and Experimental Nephrology·Takaya OzekiUNKNOWN Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology
Oct 23, 2020·Clinical and Experimental Nephrology·Gabriel StefanGabriel Mircescu
Jan 6, 2021·CEN Case Reports·Yuki ChibaMariko Miyazaki

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Methods Mentioned

BETA
biopsy
light microscopy

Software Mentioned

R
JNSCS

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