Incidence of staphylococcal colonization and of the 753Q Toll-like receptor 2 variant in nasal polyposis

American Journal of Rhinology & Allergy
Florian SachseClaudia Rudack

Abstract

The impact of Staphylococcus aureus on the development of chronic sinusitis with nasal polyps (nasal polyposis [NP]) is a controversial discussion because different S. aureus colonization rates have been reported. Aside from the presence of a microbial stimulus, elements of innate immunity such as Toll-like receptors (TLRs) and/or impaired TLR function could be relevant for the development of this disease. Because the 753Q TLR2 variant may predispose to staphylococcal infection, we simultaneously analyzed staphylococcal colonization and the R753Q TLR2 single nucleotide polymorphism (SNP) in NP. Sixty-eight patients with NP (47 men and 21 women; mean age [+/-SD], 51.8 years [16.3]) and 51 controls (32 men and 19 women; mean age [+/-SD], 36.3 years [12.2]) were included. Patient characteristics studied included status of allergy, asthma, aspirin intolerance, and endoscopic and CT polyp score. For detection of bacteria, standard procedures of bacteriology and 16S rRNA gene sequencing were used. The R753Q TLR2 polymorphism was studied by allelic discrimination assay. Overall, 128 isolates were cultured from 68 NP specimens, with Staphylococcus epidermidis and S. aureus being the most frequent bacterial isolates. Other bacterial spe...Continue Reading

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Methods Mentioned

BETA
genotyping
Biopsy

Software Mentioned

SDS

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