Incidence of symptomatic vertebral fractures in women of childbearing age newly treated with high-dose glucocorticoid

Gender Medicine
Takao SugiyamaIchiro Tatsuno

Abstract

The treatment and prevention of glucocorticoid (GC)-induced osteoporosis have been controversial in premenopausal women during their childbearing years. This study assessed the incidence and risk factors for symptomatic vertebral fracture in women of childbearing age newly treated with high-dose GC. An observational cohort study was conducted at the rheumatic center of Shimoshizu National Hospital in Chiba, Japan, from 1986 to 2006. The prevalence of symptomatic vertebral fractures, as determined by x-rays, was assessed in premenopausal (aged <50 years) women with collagen vascular disease newly treated with high-dose GC (> or =20 mg/d prednisolone equivalent) compared with their counterparts who did not receive GC. Differences in the incidences of vertebral fractures were compared between groups by the Kaplan-Meier method and evaluated by the log-rank test. Hazard ratios (HRs) with 95% CIs were estimated using the Cox proportional hazards regression model. A total of 373 women were assessed: 292 patients in the high-dose GC treatment group (mean [SD] initial age, 32.4 [8.2] years; initial dose, 43.8 [14.9] mg/d; follow-up time, 124.2 [75.4] months) and 81 patients in the non-GC control group (initial age, 39.3 [7.8] years; fol...Continue Reading

References

Jan 1, 1997·Current Opinion in Rheumatology·C A Langford
Oct 23, 1997·Current Opinion in Pulmonary Medicine·S Nagai, T Izumi
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·C E McEvoyD E Niewoehner
Dec 5, 2000·Alcoholism, Clinical and Experimental Research·R T Turner
Apr 24, 2001·Lupus·W W Chatham, R P Kimberly
Aug 27, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S LekamwasamK T Khaw
Oct 16, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T P van StaaC Cooper
Jan 25, 2003·The American Journal of Medicine·Don D SinS F Paul Man
May 6, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John A KanisDan Mellstrom
Sep 30, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·John A KanisAlan Tenenhouse
Oct 13, 2004·The Oncologist·David LussierRussell K Portenoy
Dec 21, 2004·Annals of the Rheumatic Diseases·C-S YeeC Gordon
Nov 23, 2005·Best Practice & Research. Clinical Rheumatology·Evan Romas
Dec 31, 2005·Alcoholism, Clinical and Experimental Research·Dennis A Chakkalakal
May 9, 2006·Trends in Endocrinology and Metabolism : TEM·Gherardo MazziottiAndrea Giustina
Jun 20, 2006·Scandinavian Journal of Gastroenterology. Supplement·R A van Hogezand, N A T Hamdy
Sep 14, 2006·Calcified Tissue International·T P van Staa
Nov 17, 2006·The New England Journal of Medicine·Mitsumasa KishimotoShinji Motojima
Dec 30, 2006·Arthritis and Rheumatism·Frank De VriesTjeerd P Van Staa
Feb 10, 2007·Rheumatic Diseases Clinics of North America·Luigi SinigagliaGerolamo Bianchi
Jun 15, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E CanalisJ P Bilezikian
Nov 16, 2007·The New England Journal of Medicine·Kenneth G SaagRobert Marcus
Jan 28, 2009·Journal of the American Geriatrics Society·Ichiro TatsunoTakao Sugiyama
Feb 3, 2009·Nature Clinical Practice. Rheumatology·William F Lems, Piet P Geusens

❮ Previous
Next ❯

Citations

Mar 22, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S LekamwasamUNKNOWN Joint IOF-ECTS GIO Guidelines Working Group
Nov 18, 2011·Reumatología clinica·Melania Martínez-MorilloSusana Holgado
Feb 25, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Hiroshi UeiEnshi Nakayama
Jan 5, 2019·British Journal of Haematology·Quentin A HillUNKNOWN British Society of Haematology in conjunction with the UK ITP forum
Feb 19, 2021·Critical Reviews in Food Science and Nutrition·Farzaneh AsoudehAhmad Esmaillzadeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Pulmonary Medicine
S Nagai, T Izumi
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
John N Clore, Linda Thurby-Hay
© 2021 Meta ULC. All rights reserved