Incidence of tonsillar cancer in northern Sweden: Impact of human papilloma virus

Oncology Letters
Christos LoizouKatarina Olofsson

Abstract

The incidence rate of tonsillar cancer is increasing worldwide. The current study identifies a parallel increase in the incidence of tonsillar cancer, human papilloma virus (HPV) and p16 expression among a population from northern Sweden, a sparsely populated area, confirming the strong association between p16 and HPV infection in tonsillar tissue. Data from the Swedish Cancer Registry was assessed to identify cases of tonsillar cancer in the northern territorial area of Sweden. HPV DNA was extracted from paraffin embedded diagnostic biopsies and detected by polymerase chain reaction using general primers Gp5+/6+ and CpI/IIG. Expression of p16 was identified by immunochemistry. Patients were grouped into urban or rural residence categories. A total of 214 cases were identified, comprising 155 (72.4%) men and 59 (27.6%) women, and 65 of these patients, who presented between 2000 and 2012, were analyzed. The overall median age for the analyzed patients was 58 years; 48 (74%) were males (median age, 57.5 years) and 17 (26%) were females (median age, 65 years). Of the 65 specimens, 59 (91%) were positive for HPV, and 62 (95%) expressed p16. The incidence of tonsillar cancer in the cohort demonstrated a 2-fold increase between 1990 ...Continue Reading

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Citations

Jan 18, 2017·Acta Oto-laryngologica·Hiroshi YoshidaTomokazu Yoshizaki
Jun 27, 2019·Laryngoscope Investigative Otolaryngology·Anna HolmKatarina Olofsson
Nov 17, 2019·European Annals of Otorhinolaryngology, Head and Neck Diseases·A HolmK Olofsson

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