Incidence of toxic optic neuropathy with low-dose ethambutol

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
H K YangJ-M Hwang

Abstract

To investigate the incidence of ethambutol (EMB) induced optic neuropathy prescribed at a relatively low dose of ≤ 15 mg/kg/day for the treatment of tuberculosis (TB) or Mycobacterium avium complex (MAC) lung disease. Patients diagnosed with TB or MAC lung disease received multidrug regimens including EMB at a single institution from August 2003 to July 2009. Visual monitoring was performed at baseline and at regular follow-up. The incidence of EMB-induced visual disturbances was evaluated. Of the 415 patients included in the study, three (0.7%) developed toxic optic neuropathy over the 6-year period. Of the 289 patients prescribed a dose of ≤ 15 mg/kg/day EMB, only one (0.3%) developed toxic optic neuropathy. The incidence of EMB-induced optic neuropathy among Koreans is estimated to be 0.7%, and can be reduced with lower doses of EMB.

Citations

Aug 2, 2017·Current Opinion in Ophthalmology·Paul D ChamberlainAndrew G Lee
Jul 20, 2019·CNS Drugs·Madison K Bangert, Rodrigo Hasbun
Aug 25, 2020·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Laura K Addy, Wendy W Harrison
Dec 12, 2020·Scientific Reports·Yung-Ju YooHee Kyung Yang
Oct 23, 2021·Frontiers in Cell and Developmental Biology·Xiao-Hui ZhangShi-Hui Wei

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