PMID: 9523804Apr 2, 1998Paper

Incidence of transient neurologic symptoms after hyperbaric subarachnoid anesthesia with 5% lidocaine and 5% prilocaine

Anesthesiology
R Martínez-BourioA Arízaga

Abstract

Hyperbaric 5% lidocaine has been associated with transient neurologic symptoms (TNSs) after spinal anesthesia. A prospective, masked, randomized study was conducted to compare the incidence of TNSs after spinal anesthesia with hyperbaric 5% lidocaine or 5% prilocaine to assess the utility of prilocaine as an alternative to lidocaine in patients having short surgical procedures. The number of patients to be enrolled (100 per group) was determined by power analysis (80%, P = 0.05) considering an incidence of TNSs after spinal anesthesia with lidocaine of at least 11% according to data reported in other studies. Two hundred patients scheduled for elective surgery expected to last <60 min were allocated at random to receive spinal anesthesia with hyperbaric 5% lidocaine or hyperbaric 5% prilocaine. Three to 5 days after spinal anesthesia, all patients were interviewed by an anesthesiologist who was blinded to the group assignment and details of the anesthetic and surgical technique using a standardized symptom checklist. Patients with symptoms underwent neurologic examination. Both groups were comparable with regard to demographic data and details of the surgical and anesthetic procedures. The incidence of TNSs in both groups was l...Continue Reading

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Citations

Sep 20, 2000·Mayo Clinic Proceedings·M E Johnson
Apr 14, 2010·Anaesthesia·M D Wiles, M H Nathanson
Dec 21, 2002·Best Practice & Research. Clinical Anaesthesiology·Francis V Salinas, Spencer S Liu
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Oct 1, 2013·Current Opinion in Anaesthesiology·Hinnerk WulfThorsten Steinfeldt

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