Incidence of tuberculosis and survival after its diagnosis in patients infected with HIV-1 and HIV-2

AIDS
Marianne A B van der SandeHilton C Whittle

Abstract

In sub-Saharan Africa, tuberculosis (TB) is the most frequently diagnosed opportunistic infection and cause of death among HIV-infected patients. HIV-2 has been associated with less immune suppression, slower disease progression and longer survival. To examine whether the incidence of TB and survival after TB are associated with CD4 cell count rather than HIV type. Clinical and immunological data were retrospectively evaluated among an open clinic-based cohort of HIV-1- and HIV-2-infected patients to determine incidence of TB (first diagnosis > 28 days after HIV diagnosis) and subsequent mortality. Patients were grouped by CD4 cell count into those with < 200, 200-500 and > 500 x 10 cells/l. Incident TB was diagnosed among 159 of 2012 patients, with 4973 person-years of observation time. In 105/159 (66.0%), the diagnosis was confirmed by direct microscopy or culture. Incidence of TB was highest in the group with < 200 x 10 cells/l (9.1/100 and 8.8/100 person-years in HIV-1 and HIV-2, respectively). Adjusted for CD4 cell count, there was no significant difference in incidence or mortality following TB between HIV-1- and HIV-2-infected patients. Mortality rate was higher in those with incident TB and HIV infection, most markedly ...Continue Reading

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Citations

Nov 1, 2011·The Lancet Infectious Diseases·Jennifer UyeiSally Guttmacher
Jan 16, 2013·AIDS Research and Human Retroviruses·Maxwell O AkanbiRobert L Murphy
Apr 5, 2005·American Journal of Respiratory and Critical Care Medicine·Catherine SeylerXavier Anglaret
Dec 24, 2010·American Journal of Respiratory and Critical Care Medicine·Asha AnandaiahNaimish R Patel
Aug 31, 2010·BMC Infectious Diseases·David J HorneChristopher H Goss
Oct 4, 2012·International Journal of STD & AIDS·P TabarsiF Altice
Jan 7, 2011·PloS One·Masja StraetemansMarieke J van der Werf
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Reza Yaesoubi, Ted Cohen
Oct 12, 2005·Archives of Medical Research·Timothy F Brewer, S Jody Heymann
Apr 17, 2015·Journal of the Royal Society, Interface·Leonid ChindelevitchTed Cohen
Jun 1, 2012·International Journal of Mycobacteriology·Payam TabarsiDavood Mansouri
Dec 17, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·C WejseF Rudolf
Jan 15, 2009·Revista Da Sociedade Brasileira De Medicina Tropical·Leonor Henriette de LannoyGustavo Adolfo Sierra Romero

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