Abstract
Between 1990 and 1994, we conducted a prospective study in five methadone maintenance clinics in San Francisco to determine the rate of tuberculosis (TB) in injection drug users, including those who were anergic. Of the 1,745 persons seen in the clinics, 1,109 completed an evaluation that included skin testing with tuberculin and at least two other antigens (mumps, tetanus, and/or Candida), as well as HIV testing. All persons with a positive tuberculin skin test (TST) and anergic individuals who had radiographic evidence of tuberculous infection (i.e., calcified granulomas) were offered isoniazid (INH) preventive therapy. The median follow-up was 22.0 mo. There were 338 (30.5%) human immunodeficiency virus (HIV)-seropositive patients and 771 (69.5%) HIV-seronegative patients; 96 (28.0%) and 336 (44.0%), respectively, had positive TSTs. Of the HIV-seropositive subjects, 108 (31.9%) had no reaction to any of the three antigens, and were therefore classified as anergic. The rate of TB among the HIV-seropositive, TST-positive patients who did not take INH preventive therapy was 5.0 per 100 person-yr, compared with 0.4 per 100 person-yr among the HIV-seronegative, TST-positive patients (p = 0.007). There were no cases of TB among th...Continue Reading
References
Feb 2, 1992·The New England Journal of Medicine·C L DaleyP C Hopewell
Mar 2, 1989·The New England Journal of Medicine·P A SelwynG H Friedland
Dec 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R R MacGregorA L Graziani
Jun 16, 1994·The New England Journal of Medicine·P M SmallG K Schoolnik
Aug 1, 1993·Annals of Internal Medicine·N MarkowitzL B Reichman
Aug 1, 1993·Annals of Internal Medicine·S MorenoD López-Gay
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·D P ChinP C Hopewell
Citations
Dec 28, 1999·Journal of Urban Health : Bulletin of the New York Academy of Medicine·J LorvickJ K Watters
Dec 17, 2009·Tuberculosis·Lu-Yu HwangEdward A Graviss
Dec 3, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert G DeissRichard S Garfein
Apr 9, 2005·Current Opinion in Pulmonary Medicine·Nicola PetrosilloPierluigi Viale
Apr 9, 2005·Current Opinion in Pulmonary Medicine·Keertan DhedaGraham A W Rook
Apr 17, 2007·Journal of Public Health Management and Practice : JPHMP·Jiehui LiUNKNOWN Tuberculosis Epidemiologic Studies Consortium
May 15, 2013·Journal of Addiction Medicine·Behnam HonarvarAlireza Hassan Abadi
Apr 24, 2009·Current Opinion in Pulmonary Medicine·Keertan DhedaMadhukar Pai
May 6, 2008·AIDS·María S SánchezWayne M Getz
Apr 13, 2011·Clinical Microbiology Reviews·Candice K Kwan, Joel D Ernst
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·D C SnyderD P Chin
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·A R MossP C Hopewell
Nov 19, 2013·PloS One·Sara C AuldWilliam R Mac Kenzie
Jan 13, 2012·Infection·U GoetschR Gottschalk
May 16, 2000·Chest·M Lauzardo, D Ashkin
Oct 9, 2001·HIV Clinical Trials·N W Schluger, J Burzynski
Jan 9, 2015·Respiratory Research·Roberto A RabinovichWilliam MacNee
May 15, 2002·Addiction Biology·José J PortuCándido Ayensa
Dec 17, 2009·Immunology·Rebecca Axelsson-RobertsonMarkus J Maeurer
Jun 28, 2007·Journal of Addictive Diseases·Shobha SwaminathanMarc N Gourevitch
May 5, 2017·Respiratory Research·Ramzi LakhdarRoberto A Rabinovich
Jun 24, 2003·AIDS·Liselotte van AstenMaria Prins