Incidence of type 1 diabetes in age groups above 15 years: facts, hypothesis and prospects for future epidemiologic research

Acta Diabetologica
G BrunoM Songini

Abstract

Although onset of type 1 diabetes can occur in adulthood, epidemiological data are scarce, limiting our potential to identify unknown determinants of the disease. Paucity of registries expanding the recruitment of incident cases up to adulthood, atypical clinical features of type 1 diabetes at onset, misclassification of type 1 as type 2 diabetes and little use of markers of β-cell autoimmunity represents major obstacles in studying the risk of type 1 diabetes in adults. New strategies in study design, data collection and analyses may overcome these problems in the future. Population-based surveys and registries including adulthood; use of etiological rather than clinical criteria to define type 1 diabetes; availability of electronic health records as prescription data sources to avoid missing data; and application of proper statistical methods will be instrumental to gain better insight on the epidemiology and natural history of the disease.

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Citations

Oct 27, 2012·Endocrinology and Metabolism Clinics of North America·Diana E StanescuTerri H Lipman
May 26, 2017·Diabetes/metabolism Research and Reviews·Yongsoo ParkZhiguang Zhou
Oct 19, 2017·European Journal of Drug Metabolism and Pharmacokinetics·Momir MikovHani Al-Salami
Mar 11, 2020·BMC Endocrine Disorders·Ciric VojislavRadenkovic Sasa
Dec 19, 2020·Diabetes Research and Clinical Practice·Jean M LawrenceAssiamira Ferrara
Jul 25, 2021·International Journal of Molecular Sciences·Witold BauerAdam Krętowski

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